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Recombination between two mouse t-haplotypes (tw12tf and tLub-1): segregation of lethal factors relative to centromere and tufted (tf) locus

Published online by Cambridge University Press:  14 April 2009

Hubert Condamine ,
Jean-Louis Guénet  and
François Jacob
Hubert Condamine
Affiliation:
Service de Génétique Cellulaire du Collège de France et de l'Institut Pasteur
Jean-Louis Guénet
Affiliation:
Unité de Génétique des Mammifères, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15
François Jacob
Affiliation:
Service de Génétique Cellulaire du Collège de France et de l'Institut Pasteur

Summary

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Recombination between two mouse t–haplotypes, tw12tf and tLub-1, was investigated by screening the tailless progeny of the cross ♀ tw12tf/tLub-1 + × ♂Ttf/+tf for the segregation of tufted phenotype, tw12 and tLub-1 lethal factors, and metacentric chromosome (since tLub-l haplotype is associated with a Robertsonian fusion involving chromosomes 4 and 17). The results give a 17% estimate of the recombination frequency between centromere and tf, with tLub-l lethal factor mapping about two-thirds of the distance from centromere to tf and the tw12 lethal factor behaving as if closely linked to tf. This further extends the findings of Silver & Artzt (1981) and of Artzt, McCormick & Bennett (1982), and shows that two t–haplotypes with quite independent laboratory histories recombine at a normal level, supporting the notion that all t–haplotypes basically share the same structure.

Type
Research Article
Information
Genetics Research , Volume 42 , Issue 3 , December 1983 , pp. 335 - 344
Copyright
Copyright © Cambridge University Press 1983

References

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