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The positions of the centromeres in linkage groups II and IX of the mouse

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon ,
Jane M. Butler  and
Richard Kemp
Mary F. Lyon
Affiliation:
M.R.C. Radiobiological Research Unit, Harwell, Berkshire
Jane M. Butler
Affiliation:
M.R.C. Radiobiological Research Unit, Harwell, Berkshire
Richard Kemp
Affiliation:
M.R.C. Radiobiological Research Unit, Harwell, Berkshire

Extract

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In mice heterozygous for translocation T(2;?)163H, and also for linkage group II markers, the cw locus shows close linkage with the point of rearrangement (about 1−2% recombination). Since T 163 was apparently formed by fusion of two chromosomes near their centromeres, this means that the centromere must lie at the cw end of linkage group II. In homozygotes for T(2; 9)138Ca the genes T and d show significant linkage, indicating that their loci are on opposite sides of the trans-location break. Since, from previous data, the break is known to be proximal to d, it must then be distal to T and, again from previous data, the order of loci hi linkage group IX must be centromere-T-tf-T 138 break.

Type
Research Article
Information
Genetics Research , Volume 11 , Issue 2 , April 1968 , pp. 193 - 199
Copyright
Copyright © Cambridge University Press 1968

References

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