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Persistence of a lethal t haplotype in a laboratory stock of outbred mice

Published online by Cambridge University Press:  14 April 2009

Lee M. Silver ,
Deborah Lukralle ,
James I. Garrels  and
Keith R. Willison
Lee M. Silver
Affiliation:
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
Deborah Lukralle
Affiliation:
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
James I. Garrels
Affiliation:
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
Keith R. Willison
Affiliation:
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
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Summary

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A cryptic, lethal t haplotype (named tLmb) has been discovered in the non-inbred MF1 laboratory stock of mice. Detailed genetic and molecular studies demonstrate a close relationship between tLmb and a well-studied t haplotype, t6, previously extracted also from a laboratory stock. It appears likely that t6 is an aberrant t haplotype derived by recombination from a tLmb-like ancestral chromosome. The persistence of tLmb through 40 years of random breeding in a laboratory stock indicates that high transmission ratio distortion is sufficient to overcome the deleterious effect of a recessive lethal gene in a mouse population.

Type
Research Article
Information
Genetics Research , Volume 43 , Issue 1 , February 1984 , pp. 21 - 25
Copyright
Copyright © Cambridge University Press 1984

References

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