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The parental origin of de novo X-autosome translocations in females with Duchenne muscular dystrophy revealed by M27ß methylation analysis

Published online by Cambridge University Press:  14 April 2009

David O. Robinson ,
Yvonne Boyd ,
David Cockburn ,
Morag N. Collinson ,
Ian Craig  and
Patricia A. Jacobs
David O. Robinson*
Affiliation:
Wessex Regional Genetics Laboratory, General Hospital, Fisherton Street, Salisbury SP2 7SX
Yvonne Boyd
Affiliation:
MRC Radiobiology Unit, Chilton, Didcot, Oxon OX11 0RD
David Cockburn
Affiliation:
Genetics Laboratory, Department of Biochemistry, South Parks Road, Oxford OX1 3QU
Morag N. Collinson
Affiliation:
Wessex Regional Genetics Laboratory, General Hospital, Fisherton Street, Salisbury SP2 7SX
Ian Craig
Affiliation:
Genetics Laboratory, Department of Biochemistry, South Parks Road, Oxford OX1 3QU
Patricia A. Jacobs
Affiliation:
Wessex Regional Genetics Laboratory, General Hospital, Fisherton Street, Salisbury SP2 7SX
*
† Corresponding author.

Summary

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The parental origin of 3 de novo X-autosome translocations in females with Duchenne Muscular Dystrophy (DMD) was studied by means of methylation analysis using the X-linked probe M27ß. In all three the translocation was found to be paternal in origin. The parental origin of X-autosome translocations in females with and without DMD is compared with other structural abnormalities of the X and with autosomal translocations.

Type
Research Article
Information
Genetics Research , Volume 56 , Issue 2-3 , October 1990 , pp. 135 - 140
Copyright
Copyright © Cambridge University Press 1990

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