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Organization of polygenic systems: Cell death modifiers from natural populations of Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

James N. Thompson Jr  and
William E. Spivey
James N. Thompson Jr
Affiliation:
Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, U.S.A.
William E. Spivey
Affiliation:
Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, U.S.A.

Summary

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Expression of three wing-cell death mutants in Drosophila melanogaster was used to survey cryptic polygenic modifiers of cell death in wild type strains. Females carrying the X-linked mutants Beadex-3, notchoid and scalloped were crossed to males from each of 20 isofemale strains. Phenotypic variation in the amount of cell death was measured in F1 mutant males that were heterozygous for polygenic loci segregating in the wild strains. As expected, each mutant uncovered a broad range of polygenic variation among strains. Yet, when cluster analyses were used to evaluate the degree of correlation among the expressions of Bx3, sd and nd, the isofemale strains could be partitioned into a small number of groups that were similar in the effects they had upon the severity of cell death. Chromosome mapping of one cell death suppressor strain demonstrated that different polygenic loci could produce the same phenotype in different mutant backgrounds.

Type
Research Article
Information
Genetics Research , Volume 44 , Issue 3 , December 1984 , pp. 261 - 269
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Boyer, B. J., Parris, D. L. & Milkman, R. (1973). The crossveinless polygenes in an Iowa population. Genetics 75, 169–179.CrossRefGoogle Scholar
Carson, H. L. (1982). Speciation as a major reorganization of polygenic balances. In Mechanisms of Speciation (ed. White, M. J. D.), pp. 411–433. New York: Alan R. Liss.Google Scholar
Fristrom, D. (1969). Cellular degeneration in the production of some mutant phenotypes in Drosophila melanogaster. Molecular and General Genetics 103, 363–379.CrossRefGoogle ScholarPubMed
Hochschild, R. (1971). Lysosomes, membranes and aging. Experimental Gerontology 6, 153–166.CrossRefGoogle ScholarPubMed
Mather, K. & Jinks, J. L. (1971). Biometrical Genetics. London: Chapman and Hall.CrossRefGoogle ScholarPubMed
Milkman, R. (1970 a). The genetic basis of natural variation in Drosophila melanogaster. Advances in Genetics 15, 55–114.CrossRefGoogle ScholarPubMed
Milkman, R. (1970 b). The genetic basis of natural variation. X. Recurrence cve eve polygenes. Genetics 65, 289–303.CrossRefGoogle Scholar
Parsons, P. A. (1973). Behavioural and Ecological Genetics: A Study in Drosophila. Oxford: Clarendon Press.Google Scholar
Parsons, P. A. (1975). Quantitative variation in natural populations. Genetics 79, 127–136.Google ScholarPubMed
Parsons, P. A. (1979). Polygenic variation in natural populations of Drosophila. In Quantitative Genetic Variation (ed. Thompson, J. N. Jr. and Thoday, J. M.), pp. 61–79. New York: Academic Press.CrossRefGoogle Scholar
Parsons, P. A. (1980). Isofemale strains and evolutionary strategies in natural populations. Evolutionary Biology 13, 175–217.CrossRefGoogle Scholar
Rohlf, F. J., Kishpaugh, J. & Kirk, D. (1979). Numerical Taxonomy System of Multivariate Statistical Programs. Manual produced by State University of New York at Stony Brook, Stony Brook, New York.Google Scholar
Sneath, P. H. A. & Sokal, R. R. (1973). Numerical Taxonomy. San Francisco: W. H. Freeman.Google Scholar
Thompson, J. N. Jr. (1974). Studies on the nature and function of polygenic loci in Drosophila. I. Comparison of genomes from selection lines. Heredity 33, 373–387.CrossRefGoogle ScholarPubMed
Thompson, J. N. Jr. (1979). Polygenic influences upon development in a model character. In Quantitative Genetic Variation (ed. Thompson, J. N. Jr. and Thoday, J. M.), pp. 243–261. New York: Academic Press.CrossRefGoogle Scholar
Thompson, J. N. Jr. & Hellack, J. J. (1982). Polygenic segregation within an isofemale strain of Drosophila. Canadian Journal of Genetics and Cytology 24, 235–241.CrossRefGoogle Scholar
Thompson, J. N. Jr. & Thoday, J. M. (1974). A definition and standard nomenclature for ‘polygenic loci’. Heredity 33, 430–437.CrossRefGoogle ScholarPubMed
Thompson, J. N. Jr. & Thoday, J. M. (1979). Quantitative Genetic Variation. New York: Academic Press.Google Scholar
Wright, S. (1980). Genie and organismic selection. Evolution 34, 825–843.CrossRefGoogle Scholar