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A new allele of the testosterone-responsive gene, Hdc-a, in the histidine decarboxylase gene complex of the mouse

Published online by Cambridge University Press:  14 April 2009

Richard J. Middleton ,
Kathleen Williamson  and
Grahame Bulfield
Richard J. Middleton
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS, UK
Kathleen Williamson
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS, UK
Grahame Bulfield*
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS, UK
*
† Corresponding author.
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In C57BL/10 and the majority of other strains of mice, females have about 20-fold higher kidney histidine decarboxylase levels than males; in DBA/2 mice, however, HDC in females is only 3- to 4-fold higher than males. The low ratio HDC phenotype of DBA/2 animals is due to decreased sensitivity of the HDC gene complex to repression by testosterone in males. From conventional crosses and by the use of the BXD recombinant inbred lines we conclude that the C57BL/ 10: DBA/2 difference, in testosterone sensitivity of HDC, is due to an allelic difference in the regulatory gene Hdc-a of the HDC gene complex, [Hdc], on chromosome 2; DBA/2 contains a third allele of this gene, Hdc-ad.

Type
Research Article
Information
Genetics Research , Volume 50 , Issue 3 , December 1987 , pp. 213 - 217
Copyright
Copyright © Cambridge University Press 1987

References

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