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Models of mitochondrial DNA transmission genetics and evolution in higher eucaryotes

Published online by Cambridge University Press:  14 April 2009

Robert W. Chapman ,
J. Claiborne Stephens ,
Robert A. Lansman  and
John C. Avise
Robert W. Chapman
Affiliation:
Department of Molecular and Population Genetics, University of Georgia, AthensGeorgia 30602
J. Claiborne Stephens
Affiliation:
Department of Molecular and Population Genetics, University of Georgia, AthensGeorgia 30602
Robert A. Lansman
Affiliation:
Department of Molecular and Population Genetics, University of Georgia, AthensGeorgia 30602
John C. Avise
Affiliation:
Department of Molecular and Population Genetics, University of Georgia, AthensGeorgia 30602
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The future value of mitochondrial DNA (mtDNA) sequence information to studies in population biology will depend in part on understanding of mtDNA transmission genetics both within cell lineages and between animal generations. A series of stochastic models has been constructed here based on various possibilities concerning this transmission. Several of the models generate predictions inconsistent with available data and, hence, their assumptions are provisionally rejected. Other models cannot yet be falsified. These latter models include assumptions that (1) mtDNA's are sorted through cellular lineages by random allocation to daughter cells in germ cell lineages; (2) the effective intracellular population sizes (nM's) of mtDNA's are small; and (3) sperm may (or may not) provide a low level ‘gene-flow’ bridge between otherwise isolated female lineages. It is hoped that the models have helped to identify and will stimulate further empirical study of various parameters likely to strongly influence mtDNA evolution. In particular, critical experiments or measurements are needed to determine the effective sizes of mtDNA populations in germ (and somatic) cells and to examine possible paternal contributions to zygote mtDNA composition.

Type
Research Article
Information
Genetics Research , Volume 40 , Issue 1 , August 1982 , pp. 41 - 57
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Avise, J. C., Lansman, R. A. & Shade, R. O. (1979 a). The use of restriction endonucleases to measure mitochondrial DNA sequence relatedness in natural populations. I. Population structure and evolution in the genus Peromyscus. Genetics 92, 279–295.CrossRefGoogle ScholarPubMed
Avise, J. C., Giblin-Davidson, C., Laerm, J., Patton, J. C. & Lansman, R. A. (1979 b). Mitochondrial DNA clones and matriarchal phylogeny within and among geographic populations of the pocket gopher, Geomys pinetis. Proceedings National Academy of Science U.S.A. 76, 6694–6698.CrossRefGoogle ScholarPubMed
Bartlett, M. S. (1966). An Introduction to Stochastic Processes with Special Reference to Methods and Applications. 2nd edition, 291 pp. Cambridge University Press.Google Scholar
Birky, C. W. Jr. (1978). Transmission genetics of mitochondria and chloroplasts. Annual Review Genetics 12, 471–512.CrossRefGoogle ScholarPubMed
Birky, C. W. & Skavaril, R. V. (1976). Maintenance of genetic homogeneity in systems with multiple genomes. Genetical Research 27, 249–265.CrossRefGoogle ScholarPubMed
Bogenhagen, D. & Clayton, D. A. (1976). Thymidylate nucleotide supply for mitochondrial DNA synthesis in mouse l-cells. Journal of Biological Chemistry 251, 2938–2944.CrossRefGoogle ScholarPubMed
Bogenhagen, D. & Clayton, D. A. (1977). Mouse L-cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle. Cell 11, 719–727.CrossRefGoogle ScholarPubMed
Brown, W. M. (1980). Polymorphism in mitochondrial DNA of humans as revealed by restriction endonuclease analysis. Proceedings National Academy of Science U.S.A. 77, 3605–3609.CrossRefGoogle ScholarPubMed
Brown, W. M. & Wright, J. W. (1979). Mitochondrial DNA analyses and the origin and relative age of parthenogenetic lizards (genus Cnemidophorus). Science 203, 1247–1249.CrossRefGoogle ScholarPubMed
Chapman, R. W. (1980). Selected Topics in Evolution Theory. Ph.D. dissertation, 83 pp. University of Georgia.Google Scholar
Coote, J. L., Szabados, G. & Work, T. S. (1979). The heterogeneity of mitochondrial DNA in different tissues from the same animal. FEBS Letters 99, 255–260.CrossRefGoogle ScholarPubMed
Crow, J. F. & Kimura, M. (1970). An Introduction to Population Genetics Theory, 591 pp. New York: Harper and Row.Google Scholar
Dawid, I. B. & Blackler, A. W. (1972). Maternal and cytoplasmic inheritance of mtDNA in Xenopus. Developmental Biology 29, 152–161.CrossRefGoogle ScholarPubMed
Fisher, R. A. (1958). The Genetical Theory of Natural Selection, 362 pp. New York: Dover Publishers.Google Scholar
Gillham, N. W. (1978). Organelle Heredity, 602 pp. New York: Raven Press.Google Scholar
Gresson, R. A. R. (1940). Presence of the sperm middle-piece in the fertilized egg of the mouse (Mus musculus). Nature 145, 425.Google Scholar
Haldane, J. B. S. (1927). A mathematical theory of natural and artifical selection. V. Selection and mutation. Proceedings of the Cambridge Philosophical Society 23, 838–844.CrossRefGoogle Scholar
H'Utchinson, C. A. III, Newbold, J. E., Potter, S. S. & Edgell, M. H. (1974). Maternal inheritance of mammalian mitochondrial DNA. Nature 251, 536–538.CrossRefGoogle Scholar
Laipis, P. J., Hauswirth, W. W., O'Brien, T. W. & Michaels, G. S. (1980). A physical map of bovine mitochondrial DNA from a single animal. Biochemica Biophysica Acta 565, 22–32.CrossRefGoogle Scholar
Lutka, A. J. (1931 a). Population analysis - the extinction of families I. Journal of the Washington Academy of Science 21, 377–380.Google Scholar
Lotka, A. J. (1931 b). Population analysis - the extinction of families II. Journal of the Washington Academy of Science 21, 453–459.Google Scholar
Michaelis, P. (1967). The investigation of plasmone segregation by pattern analysis. The Nucleus 10, 1–14.Google Scholar
Ohta, T. (1977). On the gene conversion model as a mechanism for maintenance of homogeneity in systems with multiple genomes. Genetical Research 30, 89–91.CrossRefGoogle Scholar
Ohta, T. (1980). Two-locus problems in transmission genetics of mitochondria and chloroplasts. Genetics 96, 543–555.CrossRefGoogle ScholarPubMed
Potter, S. S., Newbold, J. E., Hutchinson, C. A. III. & Edgell, M. H. (1975). Specific cleavage analysis of mammalian mitochondrial DNA. Proceedings of the National Academy of Science U.S.A. 72, 4496–4500.CrossRefGoogle ScholarPubMed
Schaffer, H. (1970). The fate of neutral mutants as a branching process, in Mathematical Topics in Population Genetics (ed. Kojima, K.), pp. 317–336. New York: Springer-Verlag.CrossRefGoogle Scholar
Spiess, E. B. (1977). Genes in Populations, 780 pp. New York: John Wiley.Google Scholar
Takahata, N. & Maruyama, T. (1981). A mathematical model of extranuclear genes and the genetic variability maintained in a finite population. Genetical Research 37, 291–302.CrossRefGoogle Scholar
Upholt, W. B. & Dawid, I. B. (1977). Mapping of mitochondrial DNA of individual sheep and goats: rapid evolution in the D loop region. Cell 11, 571–583.CrossRefGoogle ScholarPubMed
Watterson, G. A. (1962). Some theoretical aspects of diffusion theory in population genetics. Annals of Mathematical Statistics 33, 939–957.CrossRefGoogle Scholar
Wright, S. (1931). Evolution in Mendelian populations. Genetics 16, 97–159.CrossRefGoogle ScholarPubMed
Wright, S. (1943). Isolation by distance. Genetics 28, 114–138.CrossRefGoogle ScholarPubMed