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Meiotic reversion in an unstable strain of yeast

Published online by Cambridge University Press:  14 April 2009

A. P. James
A. P. James
Affiliation:
Division of Biology, National Research Council of Canada, Ottawa, Ontario K1A 0R6

Summary

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Spontaneous reversions from instability to stability were studied in a mutant homothallic strain of yeast. The mutant strain was characterized by persistent lethal sectoring attributable to the presence of a recessive locus uns1. It was found that (1) the meiotic reversion rate is about 140 times higher than the mitotic reversion rate, (2) reversions are much more common in the homozygote uns1 uns1 than in the heterozygote UNS1 unsl, (3) revertant segregants and lethal segregants tend to occur together, and (4) meiotic revertants tend to occur as twin revertants. These results indicate that reversion from unstable to stable results from genetic recombination and that, in meiosis, this recombination involves an unequal exchange at the first division.

Type
Research Article
Information
Genetics Research , Volume 21 , Issue 1 , February 1973 , pp. 17 - 27
Copyright
Copyright © Cambridge University Press 1973

References

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