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Linkage between sperm abnormality level and major urinary protein phenotype in mice

Published online by Cambridge University Press:  14 April 2009

Jozefa Styrna
Jozefa Styrna
Affiliation:
Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Karasia 6, 30–060 Krakow, Poland

Summary

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Segregation of sperm abnormality level and the pattern of major urinary proteins (MUPs) were investigated in F2 and B1 hybrid males obtained from crosses involving two contrasting inbred strains of mice: CBA/Kw (Mup-1a1a, 3·3% abnormal sperm) and C57BL/Kw (Mup-1b1b, 21·9% abnormal sperm). In the progeny of both crosses mean levels of abnormal spermatozoa were significantly higher for males typed as Mup-1b1b than for heterozygous Mup-1a1b males. Moreover, all F2 hybrid males showing very high percentages of abnormal sperm were Mup-1b1bhomozygotes. Similarly, among B1 males with a high level of deformed spermatozoa, a statistically significant majority were Mup-1b1b genotypes. Our results suggest that at least two genes which influence sperm abnormality level are segregating in these crosses. Both appear to be recessive for high sperm abnormality level, and one shows weak linkage to Mup-1 on chromosome 4.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 2 , April 1991 , pp. 135 - 138
Copyright
Copyright © Cambridge University Press 1991

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