Skip to main content Accessibility help
×
Home
Hostname: page-component-99c86f546-45s75 Total loading time: 0.239 Render date: 2021-11-29T08:15:31.395Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

The initiation and development of the hair follicle population in tabby mice

Published online by Cambridge University Press:  14 April 2009

J. H. Claxton
Affiliation:
Department of Agricultural Biology, University of New England, Armidale, N.S.W., Australia
Rights & Permissions[Opens in a new window]

Extract

HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Hair follicle initiation and development was examined in tabby mutants and compared with a previous study of this sequence in normal mice. Initiation commenced at about the 17th embryonic day and continued for 1 and possibly 2 days after birth. Although central primary follicle initiation was of shorter than normal duration, it was more rapid, with the result that the central primaries achieved a greater maximum density, and their total numbers were greater in tabby than in normal mice.

In general structural terms, follicle group development proceeded normally except that no secondary follicles appeared, and for this reason, the mature grouping pattern of follicles was comparatively simple. Central primary follicles, the first to be initiated, were evenly spaced in the skin but the later association of lateral primaries with them was unusually close, and the resulting groups of primary follicles were relatively more compact in the mutants than they were in normal mice.

No simple explanation in terms of the altered timing of follicle initiation or the reduced complexity of the follicle group could be given for the abnormalities of the tabby coat.

Selection for high and low numbers of secondary vibrissae in tabby mice produced some correlated changes in the maincoat follicle population, but there was no apparent alteration to the time of onset of initiation. Evidently selection did not simply modify the effects of the Ta gene.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1967

References

Clark, P. J. & Evans, F. C. (1954). Distance to nearest neighbour as a measure of spatial relationships in populations. Ecology, 35, 445453.CrossRefGoogle Scholar
Claxton, J. H. (1964). The determination of patterns with special reference to that of the central primary skin follicles in sheep. J. Theoret. Biol. 7, 302317.CrossRefGoogle Scholar
Claxton, J. H. (1966). The hair follicle group in mice. Anat. Bee. 154, 195208.Google ScholarPubMed
Dry, F. W. (1926). The coat of the mouse (Mus musculus). J. Genet. 16, 287340.CrossRefGoogle Scholar
Dun, R. B. & Fraser, A. S. (1959). Selection for an invariant character, vibrissa number, in the house mouse. Ausl. J. biol. Sci. 12, 506523.CrossRefGoogle Scholar
Duncan, D. B. (1955). Multiple range and multiple F tests. Biometrics, 11, 142.CrossRefGoogle Scholar
Falconer, D. S. (1952). A totally sex-linked gene in the house mouse. Nature, Lond. 169, 664665.CrossRefGoogle ScholarPubMed
Falconer, D. S. (1953). Total sex-linkage in the house mouse. Z. indukt. Abstamm.-u. Vererb-Lehre, 85, 210219.Google ScholarPubMed
Falconer, D. S., Fraser, A. S. & King, J. W. B. (1951). The genetics and development of ‘crinkled’, a new mutant in the house mouse. J. Genet. 50, 324344.CrossRefGoogle ScholarPubMed
Kindred, B. (1967). The expression of the tabby and crinkled genes in different genetic backgrounds in the mouse. Genetics, 55, 173178.Google ScholarPubMed
Mann, S. J. (1962). Pre-natal formation of hair follicle types. Anat. Bee. 144, 135141.Google Scholar
Snell, G. D. (1941). Reproduction. In Biology of the Laboratory Mouse. New York: Dover Publications.Google Scholar
Wildman, A. B. & Carter, H. B. (1939). Fibre-follicle terminology in the Mammalia. Nature, Lond. 144, 783784.CrossRefGoogle Scholar
You have Access

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

The initiation and development of the hair follicle population in tabby mice
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

The initiation and development of the hair follicle population in tabby mice
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

The initiation and development of the hair follicle population in tabby mice
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *