Hostname: page-component-6d856f89d9-8l2sj Total loading time: 0 Render date: 2024-07-16T05:57:20.119Z Has data issue: false hasContentIssue false
  • English
  • Français

The initiation and development of the hair follicle population in tabby mice

Published online by Cambridge University Press:  14 April 2009

J. H. Claxton
J. H. Claxton
Affiliation:
Department of Agricultural Biology, University of New England, Armidale, N.S.W., Australia

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Hair follicle initiation and development was examined in tabby mutants and compared with a previous study of this sequence in normal mice. Initiation commenced at about the 17th embryonic day and continued for 1 and possibly 2 days after birth. Although central primary follicle initiation was of shorter than normal duration, it was more rapid, with the result that the central primaries achieved a greater maximum density, and their total numbers were greater in tabby than in normal mice.

In general structural terms, follicle group development proceeded normally except that no secondary follicles appeared, and for this reason, the mature grouping pattern of follicles was comparatively simple. Central primary follicles, the first to be initiated, were evenly spaced in the skin but the later association of lateral primaries with them was unusually close, and the resulting groups of primary follicles were relatively more compact in the mutants than they were in normal mice.

No simple explanation in terms of the altered timing of follicle initiation or the reduced complexity of the follicle group could be given for the abnormalities of the tabby coat.

Selection for high and low numbers of secondary vibrissae in tabby mice produced some correlated changes in the maincoat follicle population, but there was no apparent alteration to the time of onset of initiation. Evidently selection did not simply modify the effects of the Ta gene.

Type
Research Article
Information
Genetics Research , Volume 10 , Issue 2 , October 1967 , pp. 161 - 171
Copyright
Copyright © Cambridge University Press 1967

References

REFERENCES

Clark, P. J. & Evans, F. C. (1954). Distance to nearest neighbour as a measure of spatial relationships in populations. Ecology, 35, 445–453.CrossRefGoogle Scholar
Claxton, J. H. (1964). The determination of patterns with special reference to that of the central primary skin follicles in sheep. J. Theoret. Biol. 7, 302–317.CrossRefGoogle ScholarPubMed
Claxton, J. H. (1966). The hair follicle group in mice. Anat. Bee. 154, 195–208.Google ScholarPubMed
Dry, F. W. (1926). The coat of the mouse (Mus musculus). J. Genet. 16, 287–340.CrossRefGoogle Scholar
Dun, R. B. & Fraser, A. S. (1959). Selection for an invariant character, vibrissa number, in the house mouse. Ausl. J. biol. Sci. 12, 506–523.CrossRefGoogle Scholar
Duncan, D. B. (1955). Multiple range and multiple F tests. Biometrics, 11, 1–42.CrossRefGoogle Scholar
Falconer, D. S. (1952). A totally sex-linked gene in the house mouse. Nature, Lond. 169, 664–665.CrossRefGoogle ScholarPubMed
Falconer, D. S. (1953). Total sex-linkage in the house mouse. Z. indukt. Abstamm.-u. Vererb-Lehre, 85, 210–219.Google ScholarPubMed
Falconer, D. S., Fraser, A. S. & King, J. W. B. (1951). The genetics and development of ‘crinkled’, a new mutant in the house mouse. J. Genet. 50, 324–344.CrossRefGoogle ScholarPubMed
Kindred, B. (1967). The expression of the tabby and crinkled genes in different genetic backgrounds in the mouse. Genetics, 55, 173–178.CrossRefGoogle ScholarPubMed
Mann, S. J. (1962). Pre-natal formation of hair follicle types. Anat. Bee. 144, 135–141.Google Scholar
Snell, G. D. (1941). Reproduction. In Biology of the Laboratory Mouse. New York: Dover Publications.Google Scholar
Wildman, A. B. & Carter, H. B. (1939). Fibre-follicle terminology in the Mammalia. Nature, Lond. 144, 783–784.CrossRefGoogle Scholar