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The independence of germ-cell genotype from somatic influence in chimaeric mice

Published online by Cambridge University Press:  14 April 2009

Anne McLaren
Anne McLaren
Affiliation:
A.R.C. Unit of Animal Genetics, Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN

Summary

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Mouse chimaeras made by aggregating embryos homozygous for nine recessive genes with embryos carrying the corresponding dominants were mated with partners of the recessive strain. Progeny were either of the recessive type for all loci examined, or showed the dominant characters at all loci. Tail length in homozygous vestigial-tail progeny was unaffected by whether the fertilizing spermatozoon had undergone maturation in a chimaera or in a control vestigial-tail male. There was thus no indication that the germ cells had been in any way modified by their intimate association with germ cells and somatic tissue of contrasting genotype in the chimaeras.

Type
Short Papers
Information
Genetics Research , Volume 25 , Issue 1 , February 1975 , pp. 83 - 87
Copyright
Copyright © Cambridge University Press 1975

References

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