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Genetic variation in β-adrenergic receptors in mice: A magnesium effect determined by a single gene

Published online by Cambridge University Press:  14 April 2009

Jasna Markovac  and
Robert P. Erickson
Jasna Markovac
Affiliation:
Department of Human Genetics, Box 015, University of Michigan Medical School, 1137 E. Catherine Street, Ann Arbor, Michigan 48109
Robert P. Erickson
Affiliation:
Department of Human Genetics, Box 015, University of Michigan Medical School, 1137 E. Catherine Street, Ann Arbor, Michigan 48109

Summary

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Genetic variation in the amount of binding of dihydroalprenolol (a potent antagonist) to hepatocyte β-adrenergic receptors has been observed among inbred strains of mice. This variation is attributed to a differential effect of magnesium on the receptors between the high and low binding strains. Evidence for a single gene controlling the magnesium effect on dihydroalprenolol binding to β-adrenergic receptors was found using recombinant inbred lines between the high and low strains. We suggest the provisional gene symbol Badm.

Type
Research Article
Information
Genetics Research , Volume 42 , Issue 2 , October 1983 , pp. 159 - 168
Copyright
Copyright © Cambridge University Press 1983

References

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