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Genetic studies of ovulation rate in the mouse

Published online by Cambridge University Press:  14 April 2009

R. B. Land  and
D. S. Falconer
R. B. Land
Affiliation:
Institute of Animal Genetics, West Mains Road, Edinburgh
D. S. Falconer
Affiliation:
Institute of Animal Genetics, West Mains Road, Edinburgh
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Genetic and physiological studies of ovulation rate, both natural and induced, in a random bred population of laboratory mice led to the following results.

(1) The heritability of natural ovulation rate in nulliparous females was 22±19%, estimated from the correlation between paternal half-sibs.

(2) Selection applied to natural ovulation in primiparous females led to a response in both directions, with a realized heritability of 31% (h2 within litters = 0·18 ± 0·013). The number of eggs shed by the High, Control and Low lines after 12 generations were respectively 21, 16 and 14.

(3) Selection applied to ovulation induced by 4 i.u. of PMS led also to a response in both directions, with a realized heritability of 22% (h2 within litters = 0·11 ± 0·038). The induced ovulation rates of the High, Control and Low lines after 12 generations were respectively 29, 19 and 14 eggs.

(4) PMS-equivalents were calculated from dose-response curves, and were found to be nearly the same in all lines except the line selected for high natural ovulation rate, which had a PMS-equivalent nearly double that of the Control. From this it was inferred that the increase of ovulation rate resulting from selection for high natural ovulation was due to an increased FSH activity, whereas the changes of ovulation rate resulting from selection for low natural ovulation and for both high and low induced ovulation were due to changes of ovarian sensitivity.

(5) Genetic correlations, estimated from correlated responses to selection, were: (i) between natural and induced ovulation in primiparous females, 0·33; (ii) between primiparous and nulliparous females in natural ovulation, 0·46; (iii) between primiparous and nulliparous females in induced ovulation, 0·82.

(6) The selection for induced ovulation produced changes in litter size following natural ovulation that were nearly equal to the changes in natural ovulation rate. The selection for natural ovulation, however, produced no clear changes of litter size.

Type
Research Article
Information
Genetics Research , Volume 13 , Issue 1 , February 1969 , pp. 25 - 46
Copyright
Copyright © Cambridge University Press 1969

References

REFERENCES

Bell, E. T. & Land, R. B. (1969). The suitability of mice selected for ovulation rate for the bioassay of gonadotrophins and the level of follicle-stimulating hormone in their pituitary glands. In preparation.Google Scholar
Bradford, G. E. (1968). Selection for litter size in mice in the presence and absence of gonadotrophin treatment. Genetics 58, 293–295.Google Scholar
Edwards, R. G. (1962). The size and endocrine activity of the pituitary in mice selected for large or small body size. Genet. Res. 3, 428–443.CrossRefGoogle Scholar
Edwards, R. G., Wilson, E. D. & Fowler, R. E. (1963). Genetic and hormonal influences on ovulation rate and implantation in adult mice treated with gonadotrophins. J. Endocrin. 26, 389–399.CrossRefGoogle Scholar
Falconer, D. S. (1960 a). The genetics of litter size in mice. J. Cell. Comp. Physiol. 56 (suppl. 1), 153–167.CrossRefGoogle Scholar
Falconer, D. S. (1960 b). Introduction to Quantitative Genetics. Edinburgh: Oliver and Boyd.Google Scholar
Falconer, D. S. (1963). Quantitatively different responses to selection in opposite directions. In Statistical Genetice and Plant Breeding. Eds. Hanson, W. D. and Robinson, H. F.. Nat. Acad. Sci.—Nat. Res. Council, Washington. Publ. no. 982, pp. 487–490.Google Scholar
Falconer, D. S., Edwards, R. G., Fowler, B. E. & Roberts, R. C. (1961). Analysis of differences in the number of eggs shed by the two ovaries of mice during natural oestrus or after superovulation. J. Reprod. Fertil. 2, 418–434.CrossRefGoogle ScholarPubMed
Festing, M. (1968). Some aspects of reproductive performance in inbred mice. Lab. Anim. 2, 89–100.CrossRefGoogle Scholar
Fowler, R. E. & Edwards, R. G. (1957). Introduction of superovulation and pregnancy in mature mice by gonadotrophins. J. Endocrin. 15, 374–384.Google Scholar
Fowler, R. E. & Edwards, R. G. (1960). The fertility of mice selected for large or small body size. Genet. Res. 1, 393–407.Google Scholar
Land, R. B. (1965 a). A genetic study of fertility in the mouse. Ph.D. Thesis, University of Edinburgh.Google Scholar
Land, R. B. (1965 b). Ovarian response of mice to low doses of hormones with follicle-stimulating activity. Nature, Lond. 206, 939–940.CrossRefGoogle ScholarPubMed
MacArthur, J. W. (1944). Genetics of body size and related characters. II. Satellite characters associated with body size in mice. Am. Nat. 78, 224–237.CrossRefGoogle Scholar
McLaren, A. (1962). The relation between natural fecundity and response to follicle-stimulating hormone. J. Endocrin. 25, 137–144.CrossRefGoogle Scholar
McLaren, A. (1963). The distribution of eggs and embryos between sides in the mouse. J. Endocrin. 27, 157–181.CrossRefGoogle ScholarPubMed
Monteiro, L. S. & Falconer, D. S. (1966). Compensatory growth and sexual maturity in mice. Anim. Prod. 8, 179–192.Google Scholar
Price, E. (1967). The effect of domestication on the reproductive performance of the prairie deermouse, Peromyscus maniculatus Bairdii. Evolution 21, 762–770.CrossRefGoogle ScholarPubMed