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Genetic analysis of a switch in cell specificity of P lysozyme expression in molossinus mice

Published online by Cambridge University Press:  14 April 2009

Gino A. Cortopassi  and
Allan C. Wilson
Gino A. Cortopassi*
Affiliation:
Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720
Allan C. Wilson
Affiliation:
Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720
*
* Corresponding author

Summary

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An electrophoretic survey of concentrations of lysozymes M and P was carried out with seven species in the house mouse group (spretus, hortulanus, abbotti, musculus, castaneus, domesticus and molossinus). In most species M is the predominant lysozyme in all tissues tested, except the small intestine, where P predominates if present. In inbred strains of molossinus mice P is more abundant than M in all tissues tested. The phenotypes of high expression of P lysozyme and low expression of M lysozyme in peritoneal and alveolar macrophages were examined genetically. Results of interspecific crosses and backcrosses to domesticus mice support the model that the phenotypes are caused by mutation(s) tightly linked to the lysozyme locus. Alleles at the regulatory loci show additive inheritance.

Type
Research Article
Information
Genetics Research , Volume 58 , Issue 2 , October 1991 , pp. 111 - 114
Copyright
Copyright © Cambridge University Press 1991

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