Hostname: page-component-76fb5796d-skm99 Total loading time: 0 Render date: 2024-04-26T07:52:01.895Z Has data issue: false hasContentIssue false
  • English
  • Français

Gene mapping and cross-resistance in cyclodiene insecticide-resistant Drosophila melanogaster (Mg.).

Published online by Cambridge University Press:  14 April 2009

R. H. Ffrench-Constant  and
R. T. Roush
R. H. Ffrench-Constant
Affiliation:
Department of Entomology, Comstock Hall, Cornell University, Ithaca, N. Y. 14853, USA
R. T. Roush*
Affiliation:
Department of Entomology, Comstock Hall, Cornell University, Ithaca, N. Y. 14853, USA
*
* Corresponding author.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Resistance to the cyclodiene insecticide dieldrin maps to a single gene (Rdl) on the left arm of chromosome III in Drosophila melanogaster (Meigen). The gene was further mapped by the use of chromosomal deficiencies to a single letter sub-region, 66F, on the polytene chromosome. The cross-resistance spectrum of a backcrossed strain lacking elevated mixed function oxidase activity, a common resistance mechanism, was examined. Levels of resistance similar to those found in other insects were found to dieldrin, aldrin, endrin, lindane, and picrotoxinin. Strong similarity of this single major gene with that found in other cyclodiene resistant insects is suggested by its cross-resistance spectrum and chromosomal location, via homology with other Diptera. The significance of major genes in insecticide resistance is discussed.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 1 , February 1991 , pp. 17 - 21
Copyright
Copyright © Cambridge University Press 1991

References

Bender, W., Spierer, P. & Hogness, D. S. (1983). Chromosomal walking and jumping to isolate DNA from the Ace and rosy loci and the bithorax complex in Drosophila melanogaster. Journal of Molecular Biology 168, 17–33.CrossRefGoogle ScholarPubMed
Eldefrawi, A. T. & Eldefrawi, M. E. (1987). Receptors for γ-aminobutyric acid and voltage-dependent chloride channels as targets for drugs and toxicants. FASEB Journal 1, 262–271.CrossRefGoogle ScholarPubMed
ffrench-Constant, R. H., Roush, R. T., Mortlock, D. & Dively, G. P. (1990). Isolation of dieldrin resistance from field populations of Drosophila melanogaster (Diptera: Drosophilidae). Journal of Economic Entomology 83, (in the Press).CrossRefGoogle Scholar
Foster, G. G., Whitten, M. J., Konovalov, C., Arnold, J. T. A. & Maffi, G. (1981). Autosomal genetic maps of the Australian sheep blowfly, Lucilia cuprina dorsalis R-D. (Diptera: Calliphoridae) and possible correlations with the linkage maps of Musca domestica L. and Drosophila melanogaster (Mg.). Genetical Research 37, 55–69.CrossRefGoogle Scholar
Georghiou, G. P. (1986). The magnitude of the resistance problem. In Pesticide Resistance: Strategies and Tactics for Management (ed. National Academy of Sciences), pp. 14–43. Washington, D.C.: National Academy Press.Google Scholar
Herne, D. H. C. & Brown, A. W. A. (1969). Inheritance and biochemistry of OP-resistance in a New York strain of the two-spotted spider mite. Journal of Economic Entomology 62, 205–209.CrossRefGoogle Scholar
Kadous, A. A., Ghiasuddin, S. M., Matsumura, F., Scott, J. G. & Tanaka, K. (1983). Difference in the picrotoxinin receptor between the cyclodiene-resistant and susceptible strains of the German cockroach. Pesticide Biochemistry and Physiology 19, 157–166.CrossRefGoogle Scholar
Lindsley, D. L. & Grell, E. H. (1968). Genetic variations of Drosophila melanogaster. Carnegie Institution of Washington Publication 627.Google Scholar
Oppenoorth, F. J. (1985). Biochemistry and genetics of insecticide resistance. In Comprehensive Insect Physiology, Biochemistry, and Pharmacology, vol. 12. (ed. Kerkut, G. A. and Gilbert, L. I.), pp. 731–773. New York: Pergamon.Google Scholar
Robertson, J. L., Russell, R. M. & Savin, N. E. (1980). POLO: a user's guide to probit or logic analysis. United States Forestry Service General Technical Report PSW 38.Google Scholar
Schofield, P. R., Darlison, M. G., Fugita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., Seeburg, P. H. & Barnard, E. A. (1987). Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature 328, 221–227.CrossRefGoogle Scholar
Tabashnik, B. E. & Cushing, N. L. (1989). Quantitative genetic analysis of insecticide resistance: variation in fenvalerate tolerance in a diamondback moth (Lepidoptera: Plutellidae) population. Journal of Economic Entomology, 82, 5–10.CrossRefGoogle Scholar
Tanaka, K. (1987). Mode of action of compounds acting at inhibitory synapse. Journal of Pesticide Science 12, 549–560.CrossRefGoogle Scholar
Via, S. (1986). Quantitative genetic models and the evolution of pesticide resistance. In Pesticide Resistance: Strategies and Tactics for Management (ed. National Academy of Science), pp. 222–235. Washington, D.C: National Academy Press.Google Scholar
Waters, L. C. & Nix, C. E. (1988). Regulation of insecticide resistance-related cytochrome P-450 expression in Drosophila melanogaster. Pesticide Biochemistry and Physiology 30, 214–227.CrossRefGoogle Scholar
Yarbrough, J. D., Roush, R. T., Bonner, J. C. & Wise, D. A. (1986). Monogenic inheritance of cyclodiene resistance in mosquito fish, Gambusia affinis. Experientia 42, 851–853.CrossRefGoogle Scholar