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Evidence for a nonsense mutation at the niaD locus of Aspergillus nidulans

Published online by Cambridge University Press:  14 April 2009

S. D. Martinelli ,
T. J. Roberts ,
H. M. Sealy-Lewis  and
C. Scazzocchio
S. D. Martinelli
Affiliation:
Department of Botany, Birkbeck College, (University of London), Malet Street, London WC1E 7HX
T. J. Roberts
Affiliation:
Department of Botany, Birkbeck College, (University of London), Malet Street, London WC1E 7HX
H. M. Sealy-Lewis
Affiliation:
Department of Biology, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ
C. Scazzocchio
Affiliation:
Department of Biology, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ

Summary

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Two mutations at the niaD locus (structural gene for nitrate reductase apo-protein) are genotypically suppressible. Both mutations result in loss of nitrate reductase enzyme activity and cross reacting material and are non complementing, nonleaky and highly revertible. They have the properties of nonsense mutations. This implies that some of the allele specific suppressors, which act on these and alleles at several other loci, are nonsense suppressors.

Type
Research Article
Information
Genetics Research , Volume 43 , Issue 3 , June 1984 , pp. 241 - 248
Copyright
Copyright © Cambridge University Press 1984

References

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