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The estimation of the number of mutationally silent loci in saturation-mapping experiments

Published online by Cambridge University Press:  14 April 2009

John A. Barrett
John A. Barrett
Affiliation:
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH

Summary

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When the technique of saturation mapping is employed to estimate the number of loci in a distinct chromosomal region, there is always the possibility that some loci will not be detected. If the number of mutants per locus follows a Poisson distribution, the number of mutationally silent loci can be estimated. This paper describes a method for fitting such data to a Poisson distribution truncated at the zero class and a method for estimating the number of mutationally silent loci. The use of these methods is demonstrated by their application to some published data.

Type
Research Article
Information
Genetics Research , Volume 35 , Issue 1 , February 1980 , pp. 33 - 44
Copyright
Copyright © Cambridge University Press 1980

References

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