The effect of synergistic epistasis on the inbreeding load

BRIAN CHARLESWORTH

doi:10.1017/S0016672398003140

Abstract

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The magnitude of inbreeding depression in Drosophila melanogaster appears too large to be accounted for by mutational load with multiplicative fitness interactions among loci, if current estimates of mutation and selection parameters are valid. One possible explanation for this discrepancy is synergistic epistasis among the fitness effects of deleterious mutations. A simple model of the effect of synergistic epistasis on the inbreeding load is developed. This model is used to show that deleterious mutations could account for the Drosophila data on the effects of inbreeding on components of fitness such as viability.

Crossref Citations

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Charlesworth, Brian and Charlesworth, Deborah 1998. Mutation and Evolution. Vol. 7, Issue. , p. 3.

West, S A Peters, A D and Barton, N H 1998. Testing for Epistasis Between Deleterious Mutations. Genetics, Vol. 149, Issue. 1, p. 435.

Bijlsma Bundgaard and Van Putten 1999. Environmental dependence of inbreeding depression and purging in Drosophila melanogaster . Journal of Evolutionary Biology, Vol. 12, Issue. 6, p. 1125.

Korona, Ryszard 1999. Unpredictable Fitness Transitions Between Haploid and Diploid Strains of the Genetically Loaded Yeast Saccharomyces cerevisiae. Genetics, Vol. 151, Issue. 1, p. 77.

Charlesworth, B. and Wall, J. D. 1999. Inbreeding, heterozygote advantage and the evolution of neo–X and neo–Y sex chromosomes. Proceedings of the Royal Society of London. Series B: Biological Sciences, Vol. 266, Issue. 1414, p. 51.

Vassilieva, Larissa L and Lynch, Michael 1999. The Rate of Spontaneous Mutation for Life-History Traits in Caenorhabditis elegans. Genetics, Vol. 151, Issue. 1, p. 119.

Whitlock, Michael C. and Bourguet, Denis 2000. FACTORS AFFECTING THE GENETIC LOAD IN DROSOPHILA: SYNERGISTIC EPISTASIS AND CORRELATIONS AMONG FITNESS COMPONENTS. Evolution, Vol. 54, Issue. 5, p. 1654.

Peters, Andrew D and Keightley, Peter D 2000. A Test for Epistasis Among Induced Mutations in Caenorhabditis elegans . Genetics, Vol. 156, Issue. 4, p. 1635.

Aspi, Jouni 2000. Inbreeding and outbreeding depression in male courtship song characters in Drosophila montana. Heredity, Vol. 84, Issue. 3, p. 273.

Hedrick, Philip W. and Kalinowski, Steven T. 2000. Inbreeding Depression in Conservation Biology. Annual Review of Ecology and Systematics, Vol. 31, Issue. 1, p. 139.

Wloch, D. M. Borts, R. H. and Korona, R. 2001. Epistatic interactions of spontaneous mutations in haploid strains of the yeast Saccharomyces cerevisiae . Journal of Evolutionary Biology, Vol. 14, Issue. 2, p. 310.

Morgan, M. T. 2001. Consequences of life history for inbreeding depression and mating system evolution in plants. Proceedings of the Royal Society of London. Series B: Biological Sciences, Vol. 268, Issue. 1478, p. 1817.

Templeton, Alan R. 2002. The Speke's Gazelle Breeding Program as an Illustration of the Importance of Multilocus Genetic Diversity in Conservation Biology: Response to Kalinowski et al.. Conservation Biology, Vol. 16, Issue. 4, p. 1151.

Marr, Amy B. Keller, Lukas F. and Arcese, Peter 2002. HETEROSIS AND OUTBREEDING DEPRESSION IN DESCENDANTS OF NATURAL IMMIGRANTS TO AN INBRED POPULATION OF SONG SPARROWS (MELOSPIZA MELODIA). Evolution, Vol. 56, Issue. 1, p. 131.

Cuevas, José M Elena, Santiago F and Moya, Andrés 2002. Molecular Basis of Adaptive Convergence in Experimental Populations of RNA Viruses. Genetics, Vol. 162, Issue. 2, p. 533.

Meffert, Lisa M. Hicks, Sara K. and Regan, Jennifer L. 2002. Nonadditive Genetic Effects in Animal Behavior. The American Naturalist, Vol. 160, Issue. S6, p. S198.

Van Oosterhout, C. Trigg, R. E. Carvalho, G. R. Magurran, A. E. Hauser, L. and Shaw, P. W. 2003. Inbreeding depression and genetic load of sexually selected traits: how the guppy lost its spots. Journal of Evolutionary Biology, Vol. 16, Issue. 2, p. 273.

Regan, J. L. Meffert, L. M. and Bryant, E. H. 2003. A direct experimental test of founder-flush effects on the evolutionary potential for assortative mating. Journal of Evolutionary Biology, Vol. 16, Issue. 2, p. 302.

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The effect of synergistic epistasis on the inbreeding load

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