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Curtailed, a new dominant T-allele in the house mouse

Published online by Cambridge University Press:  14 April 2009

A. G. Searle
A. G. Searle
Affiliation:
M.R.C. Radiobiological Research Unit, Harwell, Berkshire

Extract

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Curtailed (Tc) is a new T-allele which leads to complete or near-complete absence of the tail in heterozygotes, apart from a small caudal filament. Other heterozygous defects include absence of the axis odontoid process and of the nuclei pulposi, a tendency to have rib and vertebral fusions and a slight decrease in the average number of presacral vertebrae. Tc is lethal when homozygous, causing similar but more extreme defects than T, with absence of all limb-buds and non-closure of the neural folds. A comparison of Tc with other mutants suggests that the anomalies are mainly the result of more severe effects on the notochord-mesoderm system than in T. Differences between the genetic behaviour of T, Tc and Th are discussed.

Type
Research Article
Information
Genetics Research , Volume 7 , Issue 1 , February 1966 , pp. 86 - 95
Copyright
Copyright © Cambridge University Press 1966

References

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