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The control of mutational instability by a new mutator gene of Drosophila melanogaster*

Published online by Cambridge University Press:  14 April 2009

R. C. Woodruff
R. C. Woodruff
Affiliation:
Department of Genetics, University of Cambridge, Cambridge CB4 1XH, England

Summary

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The isolation and genetic characterization of a new mutator gene, Mutator-forked3N (Mu-f3N), of Drosophila melanogaster are described. This mutator gene is unique in that it seems to increase specifically the reversion frequency of the unstable mutant forked3N (f3N, 1–56.7), since the frequency of spontaneous sex-linked recessive lethals in males and females and the frequency of reverse mutations at eight additional X-linked alleles were unaffected by Mu-f3N. The mutator is a dominant gene that has been mapped to the region between f3N (1–56.7) and Beadex-2 (Bx2, 1–59.4) in the X chromosome, and it seems to function only in the ‘ cis’ configuration. The mode of action of Mu-f3N is compared with that of other mutator genes.

Type
Research Article
Information
Genetics Research , Volume 25 , Issue 2 , April 1975 , pp. 163 - 177
Copyright
Copyright © Cambridge University Press 1975

References

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