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Complementation reactions of a lethal mouse t-haplotype believed to include a deletion

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon ,
Susan E. Jarvis ,
Irene Sayers  and
D. R. Johnson
Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon., U.K.
Susan E. Jarvis
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon., U.K.
Irene Sayers
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon., U.K.
D. R. Johnson
Affiliation:
Department of Anatomy, University of Leeds, U.K.

Summary

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The lethal t-haplotypes of the mouse fall into several distinct complementation groups, and varying degrees of partial complementation occur when haplotypes from different groups are crossed. The haplotype th20 arose as a mutant from the haplotype t6, and is thought to include a small deletion covering loci near the t-lethals. In this paper the complementarity of th20 was compared with that of its parent haplotype t6. th20 showed weaker complementation than t6 of the haplotypes tw5, tw32 and tw1. Hence the loci of these lethals were probably exposed by the deletion in th20. However, th20 showed full complementation of tw18 and showed full viability in compound with the dominant brachyury allele hairpin-tail, Thp. Therefore, the th20 deletion probably does not overlap the presumed deletion in Thp, nor extend to the locus of the tw18 lethal. The significance of the weak complementation of tw5, tw32 and tw1 is discussed.

Type
Research Article
Information
Genetics Research , Volume 33 , Issue 2 , April 1979 , pp. 153 - 161
Copyright
Copyright © Cambridge University Press 1979

References

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