Hostname: page-component-848d4c4894-75dct Total loading time: 0 Render date: 2024-06-07T09:16:03.522Z Has data issue: false hasContentIssue false
  • English
  • Français

‘Bare’, a new hairless mutant in the mouse—genetics and histology

Published online by Cambridge University Press:  14 April 2009

Homai P. Randelia  and
L. D. Sanghvi
Homai P. Randelia
Affiliation:
Indian Cancer Research Centre, Parel, Bombay 12, India
L. D. Sanghvi
Affiliation:
Indian Cancer Research Centre, Parel, Bombay 12, India

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. A new hereditary defect affecting the hair coat of Swiss albino mice is described. The defect was found to be inherited as a recessive character and is designated as bare (ba).

2. The gene affected the vibrissae as well as pelage hairs. The lack of vibrissae and other sensory hairs at birth, helped to differentiate them easily from the normal animals. The first hairs on the body appeared at 13–14 days of age. The hairs were thin and tiny and remained there till about the thirtieth day. The hairs in the second hair cycle appeared at about 45 days, and again disappeared within 10 days. The animals were entirely naked when they were 6 months old.

3. Gross as well as microscopic examination of hairs in the first hair cycle did not show the four different normal types of hairs. The hairs were comparatively very small, thin, and the internal structure did not show any regularity in the arrangement of the air cells.

4. No difference was found in the number of hair follicles in the bare and the normal Swiss mice.

5. Histology revealed the presence of keratinized globular masses instead of straight hair. This abnormality persisted in all the hair cycles.

6. The bare mice were compared with the other mutants and placed in the Alopecia-Naked group where the abnormality was in the keratinization of the hair.

Type
Research Article
Information
Genetics Research , Volume 2 , Issue 2 , July 1961 , pp. 283 - 289
Copyright
Copyright © Cambridge University Press 1961

References

REFERENCES

Carter, T. C. & Phillips, R. J. S. (1954). Ragged, a semidominant coat texture mutant in the house mouse. J. Hered. 45, 151.CrossRefGoogle Scholar
Chase, H. B. (1954). Growth of the hair. Physiol. Rev. 34, 113.CrossRefGoogle ScholarPubMed
David, L. T. (1931). Hairless mammals. Comparative histologic studies, preliminary report. Arch. Derm. Syph., N.Y., 24, 196.CrossRefGoogle Scholar
Dickie, M. M. (1955). Alopecia, a dominant mutation in the house mouse. J. Hered. 46, 31.CrossRefGoogle Scholar
Dry, F. W. (1926). The coat of the mouse (Mus musculus). J. Genet. 16, 287.CrossRefGoogle Scholar
Falconer, D. S. (1953). Total sex linkage in the house mouse. Z. indukt. Abstamm.-u. VererbLehre, 85, 210.Google ScholarPubMed
Falconer, D. S., Fraser, A. S. & King, J. W. (1951). The genetics and development of crinkled, a new mutant in the house mouse. J. Genet. 50, 324.CrossRefGoogle ScholarPubMed
Fraser, F. C. (1946). The expression and interaction of hereditary factors producing hypotrichosis in the mouse; histology and experimental results. Canad. J. Res. 24D, 10.CrossRefGoogle Scholar
Gordon (1850). Cited by David (1931).Google Scholar
Howard, A. (1940). ‘Rhino’, an allele of hairless in the house mouse. J. Hered. 31, 467.CrossRefGoogle Scholar
Jarrett, A. & Spearman, R. I. (1957). Keratin defect and hair cycle of a new mutant (matted) in the house mouse. J. Embryol. exp. Morph. 5 (1), 103.Google Scholar
Liang, H. M. (1948). Localised changes in methylcholanthrene treated epidermis. Cancer Res. 8, 211.Google ScholarPubMed
Makino, S. (1950). A hairless mutation in Asiatic tame mice. J. Hered. 41, 257.CrossRefGoogle ScholarPubMed
Montagna, W., Chase, H. B. & Melaragno, H. P. (1952). The skin of hairless mice. I. The formation of cysts and the distribution of lipids. J. invest. Derm. 19, 83.CrossRefGoogle ScholarPubMed
Rigdon, R. H. & Packchanian, A. A. (1957). Histologic study of the skins of hairless American deer mice (Peromyscus maniculatus gambeli). A.M.A. Arch. Path. 64, 210.Google ScholarPubMed
Searle, A. G. & Spearman, R. J. (1957). ‘Matted’—A new hair mutant in the house mouse. Genetics and morphology. J. Embryol. exp. Morph. 5 (1), 93.Google Scholar
Wolbach, S. B. (1951). The hair cycle of the mouse and its importance in the study of sequences of experimental carcinogenesis. Ann. N.Y. Acad. Sci. 53, 517.CrossRefGoogle Scholar