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Allele frequency changes in artificial selection experiments: statistical power and precision of QTL mapping

Published online by Cambridge University Press:  01 April 1999

YUSEOB KIM  and
WOLFGANG STEPHAN
YUSEOB KIM
Affiliation:
Department of Biology, University of Rochester, Rochester, NY 14627-0211, USA
WOLFGANG STEPHAN
Affiliation:
Department of Biology, University of Rochester, Rochester, NY 14627-0211, USA

Abstract

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A simple mathematical model of genic directional selection is developed to study frequency changes of genetic marker alleles that are partially linked to a quantitative trait locus (QTL) under artificial selection. The effects of population size, number of generations of artificial selection, recombination between marker locus and QTL, and the strength of selection on the change in allele frequency are analysed by the diffusion equation approach and by stimulation. Using these results, we investigate the power of statistical tests for the detection of QTLs based on the observation of significant marker allele frequency changes in selection experiments. The probability of inferring the correct location of a QTL is also obtained.

Type
Research Article
Information
Genetics Research , Volume 73 , Issue 2 , April 1999 , pp. 177 - 184
Copyright
© 1999 Cambridge University Press