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Accumulation of mutations affecting body weight in inbred mouse lines

Published online by Cambridge University Press:  14 April 2009

Armando Caballero ,
Peter D. Keightley  and
William G. Hill
Armando Caballero*
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT. Phone: 0131-650 5443, Fax: 0131-650 6564, E.mail: eang60@castle.ed.ac.uk
Peter D. Keightley
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT. Phone: 0131-650 5443, Fax: 0131-650 6564, E.mail: eang60@castle.ed.ac.uk
William G. Hill
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT. Phone: 0131-650 5443, Fax: 0131-650 6564, E.mail: eang60@castle.ed.ac.uk
*
* Corresponding author.
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The variation from spontaneous mutations for 6-week body weight in the mouse was estimated by selection from a cross of two inbred sublines, C57BL/6 and C57BL/10, separated about 50 years previously from the same inbred line. Selection was practised high and low for 12 generations from the F2, followed by one generation of relaxation. The lines diverged by approximately 1·7 g or 0·7 sd. The additive genetic variance was estimated in the F2 by restricted maximum likelihood and from the selection response, and from this variance the mutational heritability hM2 was estimated using the number of generations since divergence. Estimates of hM2 range from 0·08 to 0·10% depending on the method of analysis. These estimates are similar to those found for other species, but lower than other estimates for the mouse. It is concluded that substantial natural and, perhaps, artificial selection operated during the maintenance of the sublines.

Type
Short Paper
Information
Genetics Research , Volume 65 , Issue 2 , April 1995 , pp. 145 - 149
Copyright
Copyright © Cambridge University Press 1995

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