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5-azacytidine-induced decrease in the frequency of Barr body in human fibroblasts

Published online by Cambridge University Press:  14 April 2009

Asit B. Mukherjee ,
Deborah C. Luckett  and
Rene J. Herrera
Asit B. Mukherjee
Affiliation:
Department of Biological Sciences, Fordham University, Bronx, N.Y. 10458, U.S.A.
Deborah C. Luckett
Affiliation:
Department of Biological Sciences, Fordham University, Bronx, N.Y. 10458, U.S.A.
Rene J. Herrera
Affiliation:
Department of Biology and Biotechnology, Worcester Polytechnique Institute, Worcester, MA 01609, U.S.A.

Summary

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5-azacytidine-treated human fibroblasts exhibit a significant decrease in the frequencies of Barr body+ cells as compared to nontreated cultures. This presumably indicates that 5-azacytidine can induce a change in the degree of condensation of the Barr body. It is suggested that the state of chromatin condensation of the Barr body may be related to the reactivation process by 5-azacytidine of gene loci in the inactive X.

Type
Research Article
Information
Genetics Research , Volume 47 , Issue 3 , June 1986 , pp. 199 - 203
Copyright
Copyright © Cambridge University Press 1986

References

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