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Meconium ileus: antenatal diagnosis and perinatal care

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  15 January 2010

Michael S Irish ,
Yvonne Gollin ,
Drucy S Borowitz ,
Stuart O'Toole  and
Philip L Glick
Michael S Irish
Affiliation:
The Buffalo Institute of Fetal Therapy (BIFT), The Childrens Hospital of Buffalo, Departments of Pediatric Surgery, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, U.S.A.
Yvonne Gollin
Affiliation:
Departments of Perinatology Surgery, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, U.S.A.
Drucy S Borowitz
Affiliation:
Departments of Pediatrics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, U.S.A.
Stuart O'Toole
Affiliation:
The Buffalo Institute of Fetal Therapy (BIFT), The Childrens Hospital of Buffalo, Departments of Pediatric Surgery, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, U.S.A.
Philip L Glick*
Affiliation:
The Buffalo Institute of Fetal Therapy (BIFT), The Childrens Hospital of Buffalo, Departments of Pediatric Surgery, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, U.S.A. Departments of Pediatrics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, U.S.A.
*
Philip L. Glick, Buffalo Institute of Fetal Therapy, Childrens Hospital of Buffalo, State University of New York at Buffalo, 219 Bryant Street, Buffalo, New York 14222, U.S.A.
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Extract

Meconium ileus (MI) is one of the most common causes of intestinal obstruction in the newborn accounting for 9–33% of neonatal intestinal obstructions. It is the earliest clinical manifestation of cystic fibrosis (CF), occurring in approximately 16% of patients with CF. However, MI has been reported in the absence of CF.

Type
Research Article
Information
Fetal and Maternal Medicine Review , Volume 8 , Issue 2 , May 1996 , pp. 79 - 93
Copyright
Copyright © Cambridge University Press 1996

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References

1de Lorimier, AA, Fonkalsrud, EW, Hays, DM. Congenital atresia and stenosis of the jejunum and ileum. Surgery 1969; 65: 819–27.Google ScholarPubMed
2FitzSimmons, SC. The changing epidemiology of cystic fibrosis. J Pediatr 1993; 122: 1–9.CrossRefGoogle ScholarPubMed
3Borowitz, D. Pathophysiology of gastrointestinal complications of cystic fibrosis. Seminars Resp Crii Care Med 1994; 15: 391–01.CrossRefGoogle Scholar
4Rickman, PD, Boeckman, CR. Neonatal meconium obstruction in the absence of mucoviscidosis. Am J Surg 1965; 109: 173–77.Google Scholar
5Vinograd, I, Mogie, P, Peleg, O, Alpan, G, Lernau, OZ. Meconium disease in premature infants with very low birth weight. J Pediatr 1983; 103: 963–66.CrossRefGoogle ScholarPubMed
6Wilcox, DT, Borowitz, DS, Stovroff, MC, Glick, PL. Chronic intestinal pseudo-obstruction with meconium ileus at onset. J Pediatr 1993: 123: 751–52.CrossRefGoogle ScholarPubMed
7Olsen, MM, Luck, SR, Lloyd-Still, J, Raffensperger, JG. The spectrum of meconium disease in infancy. J Pediatr Surg 1982; 17: 479–81.CrossRefGoogle ScholarPubMed
8Gillis, DA, Grantmyre, EB. The meconium plug syndrome and Hirshsprung s disease. Can Med Assoc J 1965; 92: 225–27.Google Scholar
9Dolan, TF, Touloukian, RJ. Familial meconium ileus not associated with cystic fibrosis. J Pediatr Surg 1974; 9: 821–24.CrossRefGoogle Scholar
10Déchelotte, PJ, Mulliez, NM, Bouvier, RJ, Vanlieféringhen, PC, Lémery, DJ. Pseudo-meconium ileus due to cytomegalovirus infection: a report of three cases. Pediatr Pathol 1992; 12: 73–82.CrossRefGoogle ScholarPubMed
11Hurwitt, ES, Arnheim, EE. Meconium ileus associated with stenosis of the pancreatic ducts. Am J Dis Child 1942; 64: 443–54.CrossRefGoogle Scholar
12Landsteiner, K. Darmverschluss durch eingedicktes meconium: pancreatitis. Zentralbl Alig Pathol 1905; 16: 903–907.Google Scholar
13Fanconi, G, Uehlinger, E, Knauer, C. Das coeliakiesyndrom bei angeborener zystishcer pancreasfibromatose und bronchiektasien. Wien Med Wochenschr 1936; 27/28: 753–56.Google Scholar
14Anderson, DH. Cystic fibrosis of the pancreas and its relation to celiac disease. Am J Dis Child 1938; 56; 344–99.CrossRefGoogle Scholar
15Glanzmann, E. Dysporia entero-broncho-pancreatica congenita familiáris. Ann Paediat 1946; 166: 289.Google ScholarPubMed
16Buchanan, DJ, Rapoport, S. Chemical comparison of normal meconium and meconium from patients with meconium ileus. Pediatrics 1952; 9: 304–10.CrossRefGoogle ScholarPubMed
17Bodian, M, editor. Fibrocystic disease of the pancreas: congenital disorder of mucous production-mucosis. New York: Grane and Stratton Inc. 1953.Google Scholar
18Riordan, JR, Rommens, JM, Kerem, B, Alon, N, Rozmahel, R, Grzelczak, Z et al. Identification of the cystic fibrosis gene: cloning and characterization of complimentary DNA. Science 1989; 245: 1066–73.CrossRefGoogle Scholar
19Bear, CE, Li, CH. Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR). Cell 1992; 68: 809–18.CrossRefGoogle ScholarPubMed
20Welsh, MJ, Anderson, MP, Rich, DP, Berger, HA. Cystic fibrosis transmembrane conductance regulator: a chloride channel with novel regulation. Neuron 1992; 8: 821–29.CrossRefGoogle ScholarPubMed
21Tsui, LC, Buetow, K, Buchwald, M. Genetic analysis of cystic fibrosis using linked DNA markers. Am J Hum Genet 1989; 43: 645–63.Google Scholar
22Boat, TF, Welsh, MJ, Beaudet, AL. Cystic fibrosis. In: Scriver, CR, Beaudet, AL, Sly, WS, Valle, D, eds. The metabolic basis of inherited disease. New York: McGraw-Hill, 1989: 2649–80.Google Scholar
23Kerem, E, Corey, M, Kerem, B, Rommens, J, Markiewicz, D, Levison, H et al. Relationship between genotype and phenotype in CF - analysis of the most common mutation (AF508). NEJM 1990; 323: 1517–22.CrossRefGoogle Scholar
24Anguiano, A, Oates, RD, Amos, JA, Dean, M, Gerrard, B, Stewart, C et al. Congenital bilateral absence of the vas deferens: a primarily genital form of cystic fibrosis. JAMA 1992; 267: 1794–97.CrossRefGoogle ScholarPubMed
25Caniano, DA, Beaver, BL. Meconium ileus: a fifteen-year experience with forty-two neonates. Surgery 1987; 102: 699–703.Google ScholarPubMed
26Green, MN, Clarke, JT, Shwachman, H. Studies in cystic fibrosis of the pancreas: protein pattern in meconium ileus. Pediatrics 1958; 21: 635.CrossRefGoogle ScholarPubMed
27Stephean, U, Busch, EW, Kollberg, H. Cystic fibrosis detection by means of a test strip. Pediatrics 1975; 55: 35–38.CrossRefGoogle Scholar
28Bronstein, MN, Sokol, RJ, Abman, SH, Chatfield, BA, Hammond, KS, Hambridge, KM et al. Pancreatic insufficiency, growth and nutrition in infants identified by newborn screening as having cystic fibrosis. J Pediatr 1992; 120: 533–40.CrossRefGoogle ScholarPubMed
29Foulkes, AG, Harris, A. Localization of expression of the cystic fibrosis gene in human pancreatic development. Pancreas 1993; 8: 3–6.CrossRefGoogle ScholarPubMed
30Farber, SJ. The relation of pancreatic achylia to meconium ileus. J Pediatr 1944; 24: 387–92.CrossRefGoogle Scholar
31Lands, L, Zinman, R, Wise, M, Kopelman, H. Pancreatic function testing in meconium disease in CF; two case reports. J Pediatrie Gastroenterol Nutr 1988; 7: 276–79.CrossRefGoogle ScholarPubMed
32Snouwaert, JN, Bridman, KK, Latour, AM, Iraj, E, Schwab, U, Gilmour, MI et al. A murine model of cystic fibrosis. J Respir Crit Care Med 1995; 151: S59–S64.CrossRefGoogle ScholarPubMed
33Emery, JL. Laboratory observations of the viscidity of meconium. Arch Dis Child 1954; 29: 34.CrossRefGoogle ScholarPubMed
34Dalzell, AM, Freestone, NS, Billington, D, Heaf, DP. Small intestineal permeability and orocaecal transit in cystic fibrosis. Arch Dis Child 1990; 65 585–88.CrossRefGoogle Scholar
35Ball, A, Stableforth, DE, Asquith, P. Prolonged small-intestinal transit time in cystic fibrosis. Br Med J 1983; 287: 1101–103.Google Scholar
36Donnison, AB, Scwachman, H, Gross, RE. A review of 164 children with meconium ileus seen at Children s Hospital Medical Center, Boston. Pediatrics 1966; 37: 1–18.CrossRefGoogle ScholarPubMed
37O Neill, JA, Grossfield, JL, Boles ET, Jr. Surgical treatment of meconium ileus. Am J Surg 1970; 119 99–105.CrossRefGoogle ScholarPubMed
38Santulli, TV. Meconium ileus. In: Holder, TM, Ashcraft, KW eds. Paediatric Surgery. Philadelphia: WB Saunders Co, 1980:.Google Scholar
39Noblett, HR. Treatment of uncomplicated meconium ileus by Gastrograffin enema: a preliminary report. J Pediatr Surg 1969; 4: 190–97.CrossRefGoogle Scholar
40Mabogunje, OA, Wang, CI, Mahour, GH. Improved survival of neonates with meconium ileus. Arch Surg 1982; 117: 37–0.CrossRefGoogle ScholarPubMed
41Allan, JL, Robbie, M, Phelan, PD, Danks, DM. Familial occurrence of meconium ileus. Eur J Pediatr 1981; 135: 291–92.CrossRefGoogle ScholarPubMed
42Kerem, B, Rommens, JM, Buchanan, JA, Markiewicz, D, Cox, TK, Chakravarti, A et al. Identification of the cystic fibrosis gene: genetic analysis. Science 1989; 245: 1073–80.CrossRefGoogle ScholarPubMed
43Rommens, JM, Iannuzzi, MC, Kerem, B, Drumm, ML, Melmer, G, Dean, M et al. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 1989; 245: 1059–65.CrossRefGoogle ScholarPubMed
44Kristidis, P, Bozon, D, Corey, M, Markiewicz, D, Rommens, J, Lap Chee, T. Genetic determination of exocrine pancreatic function in cystic fibrosis. Am J Hum Genet 1992; 50: 1178–84.Google ScholarPubMed
45Paulson, EK, Hertzberg, BS. Hyperechoic meconium in the third trimester fetus: an uncommon normal variant. J Ultrasound Med 1991; 10: 677–80.CrossRefGoogle ScholarPubMed
46Lince, DM, Pretorius, DH, Manco-Johnson, ML, Manchester, D, Clewell, WH. The clinical significance of increased echogenicity in the fetal abdomen. Am JRoentgenol 1985; 145: 683–85.CrossRefGoogle ScholarPubMed
47Fakhry, J, Reiser, M, Shapiro, LR, Schechter, A, Pait, LP, Glennon, A. Increased echogenicity in the lower fetal abdomen: a common normal variant in the second trimester. J Ultrasound Med 1986; 5: 489–92.CrossRefGoogle ScholarPubMed
48Goldstein, RB, Filley, RA, Callen, PW. Sonographic diagnosis of meconium ileus in utero. J Ultrasound Med 1987; 6: 663–66.CrossRefGoogle ScholarPubMed
49Denholm, TA, Crow, HC, Edwards, WH, Simmons, GM, Marin-Padilla, M, Bartrum, RJ. Prenatal sonographic appearance of meconium ileus in twins. Am J Roentgenol 1984; 143: 371–72.CrossRefGoogle ScholarPubMed
50Boué, A, Muller, F, Nezelof, C, Oury, JF, Duchetal, F, Dunez, F et al. Prenatal diagnosis in 200 pregnancies with 1:4 risk of cystic fibrosis. Hum Genet 1986; 74: 288–97.CrossRefGoogle Scholar
51Dicke, JM, Crane, JP. Sonographically detected hyperechoic fetal bowel: significance and implications for pregnancy management. Obstet Gynecol 1992: 80; 778–82.Google ScholarPubMed
52Benacerraf, BR, Chaudhury, AK. Hyperechoic fetal bowel in the third trimester associated with meconium ileus secondary to cystic fibrosis: A case report. J Repród Med 1989; 34: 299–300.Google Scholar
53Caspi, B, Elchalal, U, Lancet, M, Chemke, J. Prenatal diagnosis of cystic fibrosis: ultrasonographic appearance of meconium ileus in the fetus. Prenat Diagn 1988; 8: 379–82.CrossRefGoogle ScholarPubMed
54Gollin, YG, Shaffer, WK, Gollin, G, Copel, JA. Increased abdominal echogenicity in utero: a marker for intestinal obstruction. Am J Obstet Gynecol 1993; 168: 349.Google Scholar
55Nyberg, DA, Resta, RG, Luthy, DA, Hickok, DE, Mahony, BS, Hirsch, JH. Prenatal sonographic findings of Down s syndrome: review of 94 cases. Obstet Gynecol 1990; 76: 370–77.Google ScholarPubMed
56Bromley, B, Doubilet, P, Frigoletto, FD Jr, Krauss, C, Estroff, JA, Benacerraf, BR. Is fetal hyperechoic bowel on second-trimester sonogram an indication for amniocentesis? Obstet Gynecol 1994; 83: 647–52.Google ScholarPubMed
57Bahado-Singh, R, Morotti, R, Copel, JA, Mahoney, MJ. Hyperechoic fetal bowel: the perinatal consequences. Prenat Diagn 1994; 14: 981–87.CrossRefGoogle ScholarPubMed
58Forouzan, I. Fetal abdominal echogenic mass: an early sign of intrauterine cytomegalovirus infection. Obstet Gynecol 1992; 80: 535–36.Google ScholarPubMed
59Nyberg, DA, Dubinsky, T, Resta, RG, Mahony, BS, Hickok, DE, Luthy, DA. Echogenic fetal bowel during the second trimester: clinical importance. Radiology 1993; 188: 527–31.CrossRefGoogle ScholarPubMed
60Sciosia, AL, Pretorius, DH, Budorick, NE, Cahill, TC, Axelrod, FT, Leopold, GR. Second-trimester echogenic bowel and chromosomal abnormalities. Am J Obstet Gynecol 1992; 167: 889–94.CrossRefGoogle Scholar
61Nyberg, DA, Hastrup, W, Watts, H, Mack, LA. Dilated fetal bowel: a sonographic sign of cystic fibrosis. J Ultrasound Med 1987; 6 257–60.CrossRefGoogle ScholarPubMed
62Shalev, J, Navon, R, Urback, D, Mashiach, S, Goldman, B. Intestinal obstruction and cystic fibrosis: antenatal ultrasound appearance. J Med Genet 1983; 20: 229–30.CrossRefGoogle ScholarPubMed
63Wrobleski, D, Wesselhoeft, C. Ultrasonic diagnosis of prenatal intestinal obstruction. J Pediatr Surg 1979; 14: 598–600.CrossRefGoogle ScholarPubMed
64Estroff, JA, Parad, RB, Benacerraf, BR. Prevalence of cystic fibrosis in fetuses with dilated bowel. Radiology 1992; 183: 677–80.CrossRefGoogle ScholarPubMed
65Duchatel, F, Muller, F, Oury, JF, Mennesson, I, Boue, A. Prenatal diagnosis of cystic fibrosis: ultrasonography of the gallbladder at 17–19 weeks of gestation. Fetal Diagn Ther 1993; 8: 28–36.CrossRefGoogle ScholarPubMed
66Noblett, HR. Meconium ileus. In: Ravitch, MM, Welch, KJ, Benson, CD et al eds. Pediatrie Surgery. Third edition. Chicago: Year book Medical Publishers. 1979: 943–51.Google Scholar
67Andrassy, RJ, Nirgiotis, JG. Meconium disease in infancy: meconium ileus, meconium plug syndrome and meconium peritonitis. In: Holder, TM, Ashcraft, KW eds. Pediatrie Surgery. Philadelphia: WB Saunders, 1990: 331–40.Google Scholar
68Lloyd, DA. Meconium ileus. In: Welch, KJ, Randolph, JG, Ravitch, MM, O Neill, JA Jr, Rowe, MI eds. Pediatrie Surgery. Fourth edition. Chicago: Year Book Medical Publishers, Inc., 1986: 849–58.Google Scholar
69Herson, RE. Meconium ileus. Radiology 1957; 68: 568.CrossRefGoogle ScholarPubMed
70Leonidas, JC, Berdon, WE, Baker, DH, Santulli, TV. Meconium ileus and its complications: a reappraisal of plain film roentgen diagnostic criteria. Am J Roentgenol 1970; 108: 598–609.CrossRefGoogle ScholarPubMed
71White, H. Meconium ileus: a new roentgen sign. Radiology 1956; 66: 567.CrossRefGoogle ScholarPubMed
72Ziegler, MM. Meconium ileus. Curr Prob Surg 1994; 31: 731–77.CrossRefGoogle ScholarPubMed
73Rowe, MI, Fürst, AJ, Altman, DH, Poole, CA. The neonatal response to Gastrograffin enema. Pediatrics 1971; 48: 29–35.CrossRefGoogle Scholar
74Rowe, MI, Seagram, G, Weinberger, M. Gastrograffin-induced hypertonicity. Am J Surg 1973; 125: 185–88.CrossRefGoogle ScholarPubMed
75Waggett, J, Bishop, HC, Koop, CE. Experience with Gastrograffin enema. J Pediatr Surg 1970; 5: 649–54.CrossRefGoogle Scholar
76Lillie, JG, Chrispin, AR. Investigation and management of neonatal obstruction by Gastrograffin enema. Ann Radiol 1972; 15: 237–41.Google Scholar
77Ein, S, Shandling, B, Reilly, B, Stephans, CA. Bowel perforation with nonoperative treatment of meconium ileus. J Pediatr Surg 1987; 22: 146–47.CrossRefGoogle ScholarPubMed
78Lutzger, LG, Factor, SM. Effects of some water soluble contrast media on colonie mucosa. Radiology 1976; 118: 545–48.CrossRefGoogle Scholar
79Wood, BP, Katzberg, RW, Ryan, DH, Karh, FE. Diatrízoate enema: facts and fallacies of colonie toxicity. Radiology 1978; 126: 441–44.CrossRefGoogle Scholar
80Grantmyre, EB, Butler, GJ, Gillis, DA. Necrotizing enterocolitis after Renograffin-76 treatment of meconium ileus. Am J Roentgen 1981; 136: 990–91.CrossRefGoogle Scholar
81Leonidas, JC, Burry, VF, Fellows, RA, Beatty, EC. Possible adverse effect of methylglucamine diatrízoate compounds on the bowel of newborn infants with meconium ileus. Radiology 1976; 121: 693–96.CrossRefGoogle ScholarPubMed
82Hiatt, RB, Wilson, PE. Celiac Syndrome: therapy of meconium ileus: report of 8 cases with review of the literature. Surg Gynecol Obstet 1948; 87: 317–27.Google Scholar
83Gross, RE. The surgery of infancy and childhood. Philadelphia: WB Saunders Co, 1953.Google Scholar
84Bishop, HC, Koop, CE. Management of meconium ileus: resection, Roux-en-Y anastamosis and ileostomy irrigation with pancreatic enzymes. Ann Surg 1957; 145: 410–14.CrossRefGoogle Scholar
85Santulli, TV, Blanc, WA. Congenital atresia of the intestine: pathogenesis and treatment. Ann Surg 1961; 154: 939.Google ScholarPubMed
86Swenson, O. Pediatrie Surgery. Second edition. New York: Appleton-Century-Crofts, 1962.Google Scholar
87Harberg, FJ, Senekjian, EK, Pokorny, WJ. Treatment of uncomplicated meconium ileus via T-tube ileostomy. J Pediatr Surg 1981; 16: 61–63.CrossRefGoogle ScholarPubMed
88Fitzgerald, R, Conlon, K. Use of appendix stump in the treatment of meconium ileus. J Pediatr Surg 1989; 24: 899–900.CrossRefGoogle ScholarPubMed
89Hyman, PE, Everett, SL, Harada, T. Gastric acid hypersécrétion in short bowel syndrome in infants: association with extent of resection and enterai feeding. J Pediatr Gastroenterol Nutr 1986; 5: 191–97.Google Scholar
90Bower, TR, Pringle, KC, Soper, RT. Sodium deficit causing decreased weight gain and metabolic acidosis in infants with ileostomy. J Pediatr Surg 1988; 23: 567–72.CrossRefGoogle ScholarPubMed
91National Committee for Clinical Laboratory Standards. Sweat Testing: Sample Collection and Quantitative Analysis; Accepted Guideline. NCCLS document C34-A. NCCLS, Villanova, Pensylvania 19085, 1994.Google Scholar
92Rescorla, FJ, Grosfield, JL, West, KJ, Vane, DW. Changing patterns of treatment and survival in neonates with meconium ileus. Arch Surg 1989; 124: 837–40.CrossRefGoogle ScholarPubMed
93McPartlin, JF, Dickson, AS, Swain, VA. Meconium ileus: immediate and long-term survival. Arch Dis Child 1972; 47: 207–10.CrossRefGoogle ScholarPubMed
94Kerem, E, Corey, M, Kerem, B, Durie, P, Tsui, L, Levison, H. Clinical and genetic comparisons of patients with cystic fibrosis with or without meconium ileus. J Pediatr 1989; 114: 767–73.CrossRefGoogle ScholarPubMed