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Oral microbiota in cancer: could the bad guy turn good with application of polyphenols?

Published online by Cambridge University Press:  13 December 2022

Mariya Gover Antoniraj ,
Kasi Pandima Devi ,
Ioana Berindan-Neagoe ,
Seyed Fazel Nabavi ,
Hamid Reza Khayat Kashani ,
Safieh Aghaabdollahian ,
Farzaneh Afkhami ,
Philippe Jeandet ,
Zahra Lorigooini  and
Maryam Khayatkashani
...Show all authors
Mariya Gover Antoniraj
Affiliation:
Department of Biotechnology, Alagappa University (Science Campus), Karaikudi 630 003, Tamil Nadu, India
Kasi Pandima Devi*
Affiliation:
Department of Biotechnology, Alagappa University (Science Campus), Karaikudi 630 003, Tamil Nadu, India
Ioana Berindan-Neagoe
Affiliation:
Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania The Center for Advanced Medicine – Medfuture- “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania The Department for Functional Genomics and Experimental Pathology, The Oncology Institute, “Prof. Dr Ion Chiricuta”, Cluj-Napoca, Romania
Seyed Fazel Nabavi
Affiliation:
Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre, Via Cortenocera, 82030, San Salvatore Telesino, (BN), Italy Nutringredientes Research Center, Federal Institute of Education, Science and Technology (IFCE), Baturite, Ceara, Brazil
Hamid Reza Khayat Kashani
Affiliation:
Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Safieh Aghaabdollahian
Affiliation:
Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran
Farzaneh Afkhami
Affiliation:
Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran School of Dentistry, The University of Queensland, Brisbane, Qld, 4006, Australia
Philippe Jeandet
Affiliation:
Research Unit-Induced Resistance and Plant Bioprotection, University of Reims, EA 4707-USC INRAe 1488, SFR Condorcet FR CNRS 3417, 51687 Reims, France
Zahra Lorigooini
Affiliation:
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
Maryam Khayatkashani
Affiliation:
Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre, Via Cortenocera, 82030, San Salvatore Telesino, (BN), Italy
Seyed Mohammad Nabavi*
Affiliation:
Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre, Via Cortenocera, 82030, San Salvatore Telesino, (BN), Italy Nutringredientes Research Center, Federal Institute of Education, Science and Technology (IFCE), Baturite, Ceara, Brazil
*
Authors for correspondence: Kasi Pandima Devi, Seyed Mohammad Nabavi, E-mail: devikasi@yahoo.com, nabavi208@gmail.com
Authors for correspondence: Kasi Pandima Devi, Seyed Mohammad Nabavi, E-mail: devikasi@yahoo.com, nabavi208@gmail.com
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Abstract

The human oral cavity is comprised of dynamic and polynomial microbes which uniquely reside in the microenvironments of oral cavities. The cumulative functions of the symbiotic microbial communities maintain normal homeostasis; however, a shifted microbiota yields a dysbiosis state, which produces local and systemic diseases including dental caries, periodontitis, cancer, obesity and diabetes. Recent research reports claim that an association occurs between oral dysbiosis and the progression of different types of cancers including oral, gastric and pancreatic ones. Different mechanisms are proposed for the development of cancer, such as induction of inflammatory reactions, production of carcinogenic materials and alteration of the immune system. Medications are available to treat these associated diseases; however, the current strategies may further worsen the disease by unwanted side effects. Natural-derived polyphenol molecules significantly inhibit a wide range of systemic diseases with fewer side effects. In this review, we have displayed the functions of the oral microbes and we have extended the report regarding the role of polyphenols in oral microbiota to maintain healthy conditions and prevention of diseases with emphasis on the treatment of oral microbiota-associated cancer.

Keywords

Dysbiosisextra-oral cancermicrobiomeoral cancerperiodontitispolyphenol
Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 25 , 2023 , e1
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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