Hostname: page-component-7479d7b7d-c9gpj Total loading time: 0 Render date: 2024-07-08T17:49:08.552Z Has data issue: false hasContentIssue false
  • English
  • Français

Kaposi's sarcoma: the role of HHV-8 and HIV-1 in pathogenesis

Published online by Cambridge University Press:  12 February 2004

Kimberly E. Foreman
Kimberly E. Foreman
Affiliation:
Department of Pathology, Skin Cancer Research Laboratories, Loyola University Medical CentreOncology Institute – Room 302, 2160 South First Avenue, Maywood, IL 60153-5385, USA.
Get access Rights & Permissions [Opens in a new window]

Abstract

Kaposi's sarcoma (KS) is the most common neoplasm in acquired immune deficiency syndrome (AIDS) patients, with up to 20% of individuals infected with human immunodeficiency virus 1 (HIV-1) afflicted with this multifocal, systemic disease. For many years, scientists have striven to understand the complex pathogenesis of KS. Although experts generally agree on several key points [such as human herpesvirus 8 (HHV-8) being necessary but not sufficient for the development of KS], many questions still remain unanswered. This review summarises current theories on the molecular pathogenesis of KS, including the role of HHV-8, HIV-related proteins and growth factors in the initiation and progression of AIDS-related KS.

Keywords

HHV-8herpesvirusHIV-1AIDSKaposi’s sarcomaTatcytokinehuman immunodeficiency virusacquired immune deficiency syndrome
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 3 , Issue 9 , 26 March 2001 , pp. 1 - 17
Copyright
© Cambridge University Press 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)