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Human cellular immune responses against human papillomaviruses in cervical neoplasia

Published online by Cambridge University Press:  21 February 2005

Stephen Man
Stephen Man
Affiliation:
Department of Medicine, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff, CF4 4XX, Wales, UK.
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Abstract

Human papillomaviruses (HPVs) are ubiquitous DNA viruses that infect cutaneous and mucosal epithelia. A subset of HPVs infects the female genital tract, to induce cervical lesions that can progress to malignancy in some women. DNA from HPVs can be found in >94% of cervical carcinomas (CaCx) worldwide; this strong association suggests that it might be possible to develop either prophylaxis or therapies for cervical neoplasia, based on the manipulation of human immune responses against HPVs. This review examines the current research into human immune responses against HPVs in CaCx and the potential impact of this research on human health.

Keywords

human papillomavirusHPVcervical neoplasiacervical cancerCaCximmune responseCINHPV16HPV18CTLT cellscytokinecervical intraepithelial neoplasia
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 1 , Issue 5 , 3 July 1998 , pp. 1 - 19
Copyright
© Cambridge University Press 1998

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Footnotes

Corrigendum to Fig. 1 added 07/02/05