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Lactate, histone lactylation and cancer hallmarks

Published online by Cambridge University Press:  09 January 2023

Xinyu Lv ,
Yingying Lv  and
Xiaofeng Dai Open the ORCID record for Xiaofeng Dai [Opens in a new window]
Xinyu Lv
Affiliation:
Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China
Yingying Lv
Affiliation:
Department of Clinical Laboratory, Shanghai Pudong New Area People's Hospital, Shanghai 201299, China
Xiaofeng Dai*
Affiliation:
Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China
*
Author for correspondence: Xiaofeng Dai, E-mail: xiaofeng.dai@jiangnan.edu.cn
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Abstract

Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation.

Keywords

Cancerepigenesishallmarkhistone lactylationlactatetherapeutic translation
Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 25 , 2023 , e7
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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Footnotes

*

These authors contribute equally to this work.

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