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Hypothyroidism attenuates stress-induced prolactin and corticosterone release in septic rats

Published online by Cambridge University Press:  07 November 2003

T. T. Rodriguez ,
W. I. C. Albuquerque-Araújo ,
L. C. Reis ,
J. Antunes-Rodrigues  and
M. J. Ramalho
T. T. Rodriguez
Affiliation:
Department of Physiology, Health Sciences Center, Federal University of Bahia, 40110-100, Salvador, Bahia, Department of Physiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto and Department of Physiological Sciences, Federal Rural University of Rio de Janeiro, BR465, Km7, 23851-970, Seropédica, Rio de Janeiro, Brazil
W. I. C. Albuquerque-Araújo
Affiliation:
Department of Physiology, Health Sciences Center, Federal University of Bahia, 40110-100, Salvador, Bahia, Department of Physiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto and Department of Physiological Sciences, Federal Rural University of Rio de Janeiro, BR465, Km7, 23851-970, Seropédica, Rio de Janeiro, Brazil
L. C. Reis
Affiliation:
Department of Physiology, Health Sciences Center, Federal University of Bahia, 40110-100, Salvador, Bahia, Department of Physiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto and Department of Physiological Sciences, Federal Rural University of Rio de Janeiro, BR465, Km7, 23851-970, Seropédica, Rio de Janeiro, Brazil
J. Antunes-Rodrigues
Affiliation:
Department of Physiology, Health Sciences Center, Federal University of Bahia, 40110-100, Salvador, Bahia, Department of Physiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto and Department of Physiological Sciences, Federal Rural University of Rio de Janeiro, BR465, Km7, 23851-970, Seropédica, Rio de Janeiro, Brazil
M. J. Ramalho
Affiliation:
Department of Physiology, Health Sciences Center, Federal University of Bahia, 40110-100, Salvador, Bahia, Department of Physiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto and Department of Physiological Sciences, Federal Rural University of Rio de Janeiro, BR465, Km7, 23851-970, Seropédica, Rio de Janeiro, Brazil
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Abstract

We investigated the effects of sepsis, through the lipopolysaccharide (LPS)-induced inflammatory response, on plasma corticosterone and prolactin (PRL) levels during acute immobilization stress in normal and thyroidectomized rats. Thyroidectomized (TX) or sham-operated (N) rats were subjected to 120 min of immobilization stress. Rats were treated with an intraperitoneal injection of either LPS (250 µg (100 g body wt)-1) or the same volume of vehicle (saline solution), 90 min before the induction of stress. Blood samples for hormone assays were collected before sepsis and stress induction for baseline measures (-90 min), and during sepsis and immobilization stress for the measurement of prolactin and corticosterone levels by radioimmunoassay. Our results show that the thyroid hormones are necessary for a proper response of PRL and corticosterone release during immobilization stress. Although sepsis enhanced PRL secretion, this was not true of corticosterone release in either group of rats. Low levels of thyroid hormones partially block the release of PRL, but do not block corticosterone secretion during sepsis. Experimental Physiology (2003) 88.6, 755-760.

Type
Full Length Papers
Information
Experimental Physiology , Volume 88 , Issue 6 , November 2003 , pp. 755 - 760
Copyright
The Physiological Society 2003

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