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Angiotensin II type 1 (AT1) receptor blockade enhances the L-NAME-induced vasoconstriction in rat submandibular gland

Published online by Cambridge University Press:  21 May 2002

J. Vág ,
Beáta Kerémi ,
Csilla Hably ,
J. Bartha  and
Á. Fazekas
J. Vág
Affiliation:
Department of Conservative Dentistry, Semmelweis University, Mikszáth K. tér 5, Budapest 1088 and Department of Physiology, Semmelweis University Puskin u. 9, Budapest 1088, Hungary
Beáta Kerémi
Affiliation:
Department of Conservative Dentistry, Semmelweis University, Mikszáth K. tér 5, Budapest 1088 and Department of Physiology, Semmelweis University Puskin u. 9, Budapest 1088, Hungary
Csilla Hably
Affiliation:
Department of Conservative Dentistry, Semmelweis University, Mikszáth K. tér 5, Budapest 1088 and Department of Physiology, Semmelweis University Puskin u. 9, Budapest 1088, Hungary
J. Bartha
Affiliation:
Department of Conservative Dentistry, Semmelweis University, Mikszáth K. tér 5, Budapest 1088 and Department of Physiology, Semmelweis University Puskin u. 9, Budapest 1088, Hungary
Á. Fazekas
Affiliation:
Department of Conservative Dentistry, Semmelweis University, Mikszáth K. tér 5, Budapest 1088 and Department of Physiology, Semmelweis University Puskin u. 9, Budapest 1088, Hungary
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Abstract

The vasoregulatory role of nitric oxide (NO) and angiotensin II type 1 (AT1) receptors in the circulation of the submandibular gland (SMG) of rats was studied. The glandular blood flow was determined by means of laser Doppler flowmetry and rubidium isotope technique. The data obtained by these two methods correlated well (r = 0.77; P < 0.01). The AT1 receptor antagonist candesartan (0.5 mg kg-1, I.V.) reduced the vascular resistance in the SMG by 37 % (P < 0.05). By contrast, the NO synthase blocker L-NAME (15 mg kg-1, I.V.) significantly increased vascular resistance in the SMG both in candesartan-treated (P < 0.001) and non-treated (P < 0.001) animals. The increase in resistance was greater (P < 0.05) after previous blockade of AT1 receptors. These findings suggest that the AT1 receptors have an important role in the vasoregulation of the SMG in the rat. As a result of AT1 blockade, NO-dependent tone of glandular vessels may be enhanced significantly. Experimental Physiology (2002) 87.3, 327-333.

Type
Full Length Papers
Information
Experimental Physiology , Volume 87 , Issue 3 , May 2002 , pp. 327 - 333
Copyright
© The Physiological Society 2002

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