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Second-generation antipsychotics and constipation: A review of the literature

Published online by Cambridge University Press:  16 April 2020

M. De Hert ,
H. Hudyana ,
L. Dockx ,
C. Bernagie ,
K. Sweers ,
J. Tack ,
S. Leucht  and
J. Peuskens
M. De Hert*
Affiliation:
University Psychiatric Centre, Campus Kortenberg, Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
H. Hudyana
Affiliation:
University Psychiatric Centre, Campus Kortenberg, Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
L. Dockx
Affiliation:
Medical Faculty, Campus Gasthuisberg, Catholic University Louvain, O&N2, Herestraat 49-bus 700, 3000Leuven, Belgium
C. Bernagie
Affiliation:
Medical Faculty, Campus Gasthuisberg, Catholic University Louvain, O&N2, Herestraat 49-bus 700, 3000Leuven, Belgium
K. Sweers
Affiliation:
University Psychiatric Centre, Campus Kortenberg, Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
J. Tack
Affiliation:
Department of Gastroenterology, Catholic University Louvain, O&NI Herestraat 49-bus 701, 3000Leuven, Belgium
S. Leucht
Affiliation:
Department of Psychiatry and Psychotherapy, Technische Universität München, Klinikum rechts der Isar, Ismaningerstr. 22, 81675Munich, Germany
J. Peuskens
Affiliation:
University Psychiatric Centre, Campus Kortenberg, Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
*
*Corresponding author. E-mail address: marc.de.hert@uc-kortenberg.be(M. De Hert)
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Abstract

Antipsychotics are the cornerstone in the management of psychotic disorders and schizophrenia. They are effective agents but also have a wide range of side effects. In the recent literature constipation as possible side effect has received little attention. A review of the literature concerning constipation associated with antipsychotics was performed. Overall constipation is a rarely studied or reported side effect of antipsychotic medication. Nevertheless constipation is a common side effect. Antipsychotic agents differ in their liability to induce constipation. Constipation can be severe and can lead to serious consequences such as paralytic ileus, bowel occlusion and death. Active screening, monitoring and treatment are recommended. Further research on incidence, prevalence, underlying mechanisms and preventive measures is required.

Keywords

SchizophreniaAntipsychoticsSide effectsConstipationPhysical health
Type
Original article
Information
European Psychiatry , Volume 26 , Issue 1 , January 2011 , pp. 34 - 44
Copyright
Copyright © Elsevier Masson SAS 2011

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