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Searching for new markers of panic disorder – the examination of stem cells mobilization and levels of factors involved in their trafficking

Published online by Cambridge University Press:  23 March 2020

Jolanta Kucharska-Mazur ,
Marcin Jabłoński ,
Maciej Tarnowski ,
Barbara Dołęgowska ,
Z. Ratajczak Mariusz  and
Jerzy Samochowiec
Jolanta Kucharska-Mazur*
Affiliation:
Department of Psychiatry, Pomeranian University of Medicine, Szczecin, Poland
Marcin Jabłoński
Affiliation:
Department of Psychiatry, Pomeranian University of Medicine, Szczecin, Poland
Maciej Tarnowski
Affiliation:
Department of Physiology, Pomeranian University of Medicine, Szczecin, Poland
Barbara Dołęgowska
Affiliation:
Department of Medical Analytics, Pomeranian University of Medicine, Szczecin, Poland
Z. Ratajczak Mariusz
Affiliation:
Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA
Jerzy Samochowiec
Affiliation:
Department of Psychiatry, Pomeranian University of Medicine, Szczecin, Poland
*
*Corresponding author.

Abstract

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Introduction

Regeneration processes are the new target in looking for biological markers of psychiatric disorders.

Aims

In this study, we considered the role of stem cells and factors responsible for their trafficking in panic disorder (PD).

Methods

A group of 30 patients with panic disorder was examined and compared with a group of 30 healthy volunteers. In peripheral blood we have analysed: the number of hematopoetic stem cells – HSC (Lin−/CD45+/CD34+) and HSC (Lin−/CD45+/AC133+), the number of very small embryonic – like stem cells – VSEL (Lin−/CD45−/CD34+) and VSEL (Lin−/CD45−/CD133+) and concentration of stromal derived factor-1 (SDF-1), sphingosine-1-phosphate (S1P), and some proteins of the complement cascade.

Results

Peripheral blood concentration of HSCs (Lin−/CD45+/AC133+) was significantly lower in PD group compared to control group, before and after antidepressant treatment. Peripheral blood concentration of VSEL (Lin−/CD45−/CD133+) was significantly lower in PD group before treatment compared to concentration after treatment. In PD group concentrations of factors involved in stem cell trafficking were statistically significant lower in PD group (before and after treatment) compared to control group.

Conclusion

Examination of regeneration system seems to be useful in PD diagnostics.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
FC05
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S73
Copyright
Copyright © European Psychiatric Association 2016
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