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PW01-153 - Effect Of Daao On Regional Brain Function In Healthy Individuals And Patients With Schizophrenia And Bipolar Disorder

Published online by Cambridge University Press:  17 April 2020

S.A. Papagni
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
A. Mechelli
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
D. Prata
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
J. Kambeitz
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
M. Picchioni
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
C. Fu
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
F. Kane
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
S. Kalidindi
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
C. McDonald
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
E. Kravariti
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
T. Toulopoulou
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
R. Murray
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
D. Collier
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK
P. McGuire
Affiliation:
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, UK

Abstract

Introduction

Recent studies have identified DAAO as a probable susceptibility gene for schizophrenia and bipolar disorder. However, little is known about how this gene may affect brain function to increase vulnerability to these disorders.

Objective

The present investigation examined the impact of DAAO genotype on brain function in patients with schizophrenia, patients with bipolar I disorder and healthy volunteers.

Aim

We tested the hypotheses that the high-risk variant of DAAO would be associated with altered prefrontal function and functional connectivity in schizophrenic and bipolar patients.

Methods

We used functional magnetic resonance imaging to measure brain responses during a verbal fluency task in a total of 121 subjects comprising 40 patients with schizophrenia, 33 patients with bipolar I disorder and 48 healthy volunteers. We then used statistical parametric mapping (SPM) and psycho-physiological interaction (PPI) analyses to estimate the main effects of diagnostic group, the main effect of genotype and their interaction on brain activation and functional connectivity.

Results

In schizophrenic patients relative to bipolar patients and controls, the high-risk variant of DAAO was associated with lower deactivation in the left precuneus and greater activation in the right calcarine and posterior cingulate gyrus during task performance. In addiction, these areas expressed altered functional connectivity with the rest of the brain in schizophrenic patients relative to bipolar patients and controls.

Conclusions

Our results suggest that genetic variation in DAAO has a significant impact on brain function and provide preliminary evidence for a disease-specific pattern of gene action in specific brain regions.

Type
Neuroimaging
Copyright
Copyright © European Psychiatric Association 2009
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