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Plasma glutathion peroxidase in chronic schizophrenics

Published online by Cambridge University Press:  16 April 2020

A. Intxausti ,
A.L. Morera ,
P. Abreu ,
M. Henry ,
A. Orozco  and
E. Díaz-Mesa
A. Intxausti
Affiliation:
Service of Psychiatry, University Hospital of La Candelaria, Canary Islands, Spain
A.L. Morera
Affiliation:
Department of Internal Medicine, Dermatology and Psychiatry. University of La Laguna, Canary Islands, Spain
P. Abreu
Affiliation:
Department of Physiology, University of La Laguna, Canary Islands, Spain
M. Henry
Affiliation:
Service of Psychiatry, University Hospital of The Canary Islands, Canary Islands, Spain
A. Orozco
Affiliation:
Service of Psychiatry, University Hospital of The Canary Islands, Canary Islands, Spain
E. Díaz-Mesa
Affiliation:
Service of Psychiatry, University Hospital of The Canary Islands, Canary Islands, Spain

Abstract

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Introduction:

Reduced Glutathion Peroxidase (GSH) is a common biologic marker of antioxidant status frequently used in schizophrenic research. Data regarding GSH levels in schizophrenic patients are controversial. Our objective is to study whether or not GSH levels have seasonal or circadian fluctuations in schizophrenic outpatients.

Methods:

23 clinically stable treated chronic schizophrenic outpatients were studied in summer and winter. The same day in July and January, blood samples were extracted between 8:30 and 9:00 after one night fasting. The same routine was followed during the two experimental sessions.

Results:

GSH plasma levels were not significant different between summer and winter. There was no significant difference between nocturnal and diurnal GSH levels in neither winter nor summer.

Conclusions:

Plasma GSH does not present seasonal levels either a circadian rhythm.

Type
Poster Session 1: Schizophrenia and Other Psychosis
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S116
Copyright
Copyright © European Psychiatric Association 2007
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