Skip to main content Accessibility help
×
Home
Hostname: page-component-747cfc64b6-zmlw7 Total loading time: 0.163 Render date: 2021-06-15T12:39:43.170Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Article contents

The paraspectrum study: searching for a valid paranoid psychotic phenotype

Published online by Cambridge University Press:  16 April 2020

J. Cervilla
Affiliation:
Department of Psychiatry, University of Granada, Granada, Spain
E. de Portugal
Affiliation:
Gregorio Marañón Hospital, Madrid, Spain
N. González
Affiliation:
Research and Development Unit, Sant Joan de Déu-SSM, Barcelona, Spain
V. Villalta-Gil
Affiliation:
Research and Development Unit, Sant Joan de Déu-SSM, Barcelona, Spain
M. Vilaplana
Affiliation:
Research and Development Unit, Sant Joan de Déu-SSM, Barcelona, Spain
M. Dolz
Affiliation:
Research and Development Unit, Sant Joan de Déu-SSM, Barcelona, Spain
S. Ochoa
Affiliation:
Research and Development Unit, Sant Joan de Déu-SSM, Barcelona, Spain
J. Usall
Affiliation:
Research and Development Unit, Sant Joan de Déu-SSM, Barcelona, Spain
J.M. Haro
Affiliation:
Research and Development Unit, Sant Joan de Déu-SSM, Barcelona, Spain

Abstract

Paranoid Schizophrenia (PS), yet included within the same nosological category than Non-Paranoid Schizophrenia (NPS), may in fact constitute a different disorder. In this study, the above both schizophrenia subtypes are compared with Delusional Disorder (DD). We hypothesized that, phenomenologically PS could either be a half-way category between DD and NPS or part of a phenomenological continuum of psychotic and cognitive symptoms between these three psychotic categories.

102 patients fulfilling DSM-IV-TR criteria of schizophrenia (with 56 PS and 46 with NPS) and 80 DD patients were included in this study (n=182). We compared outcome groups (DD vs. PS vs. NPS) on clinical dimensions, global functioning and sociodemographics. Clinical dimensions were extracted from the PANSS and neuropsychological scales using Principal-Component-Analysis and, subsequently, cluster analysis to assign subjects to empirically emerging clinical groups. The associations between such groups and DSM-IV-TR groups were explored using polynomial regression.

We found lineal associations demonstrating empirically that, from the psychopathological, neuropsychological and functioning perspectives, it is reasonable to consider PS as an intermediate and independent category right in between DD and NPS. Thus, the distribution of subjects assigned to three empirically emerging clinical groups (Paranoid-Affective, Paranoid-Hostile and Negative) associated, significantly and preferentially, with DSM-IV categories along the following fashion: The proportion of paranoid-hostile and, particularly, paranoid-affective subjects decreased progressively along DD, PS and NPS categories; On the contrary, the proportion of negative subjects increased lineally along those categories (Mante-Haenszel-X2= 18.02;p=0.0001). Our results question, on the bases of an empirical study, the current categorical division of paranoid psychoses.

Type
S35. Symposium: Insights in Late-Life Functional Psychosis (In Spanish)
Copyright
Copyright © European Psychiatric Association 2007
Submit a response

Comments

No Comments have been published for this article.
You have Access

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

The paraspectrum study: searching for a valid paranoid psychotic phenotype
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

The paraspectrum study: searching for a valid paranoid psychotic phenotype
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

The paraspectrum study: searching for a valid paranoid psychotic phenotype
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *