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Paired associate learning in subjects at risk for psychosis: fMRI study

Published online by Cambridge University Press:  16 April 2020

P. Fusar-Poli
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
M.R. Broome
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
P. Matthiasson
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
J. Woolley
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
L. Johns
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
P. Tabraham
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
E. Bramon
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
L. Valmaggia
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
S. Williams
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
S. Brammer
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
X. Chitnis
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
P. McGuire
Affiliation:
Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom

Abstract

Background:

Executive and mnemonic impairments have been well documented in the high-risk states for development of psychosis and have been pinpointed as a possible core neuropsychological dysfunction. However, their neurofunctional correlates are still not clear.

Method:

fMRI was used in 17 patients at risk for developing psychosis (ARMS, “at risk mental state”), 10 patients with a first episode of psychosis (FEP) and 15 age-matched healthy comparison subjects to examine neural responses to increasing difficulty of mnemonic engagement in an object–location paired associate memory task. Groups were matched in terms of age, IQ, gender, and psychopathology ratings. Accuracy and reaction time were recorded during the scan.

Results:

As the mnemonic load increased, response latency increased and response accuracy decreased in an approximately linear fashion. No main effect for group was observed. However, a trend towards decreased accuracy in FEP subjects, as compared with controls, was evident. As the task difficulty increased, increased brain activity was observed in the medial frontal cortex and in the medial posterior parietal cortex. Between-groups differences in activation were observed in a cluster spanning the MFG, SFG and SMA and in the right precuneus. However, these neurofunctional abnormalities were more evident in the most demanding level of the task than in the easy level, with the ARMS groups showing less activation than controls and higher activation than FEP.

Conclusion:

Abnormal neural activity in medial frontal cortex and posterior parietal cortex during paired associate learning task may represent a neurofunctional substrates of vulnerability to psychosis.

Type
Poster Session 2: Biological Markers And Brain Imaging
Copyright
Copyright © European Psychiatric Association 2007
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