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P-799 - Effects of the Comt x 5--httlpr Genetic Interaction on Brain Gray Matter Volume of Healthy Individuals

Published online by Cambridge University Press:  15 April 2020

J. Radua ,
W. El-Hage ,
G.C. Monté ,
B. Gohier ,
M. Tropeano ,
M.L. Phillips  and
S. Surguladze
J. Radua
Affiliation:
Research Unit, FIDMAG CIBERSAM, Sant Boi de Llobregat, Spain Psychosis Studies, Institute of Psychiatry, Kings College, London, UK
W. El-Hage
Affiliation:
INSERM U930 ERL CNRS 3106, Université François Rabelais, Tours
G.C. Monté
Affiliation:
Research Unit, FIDMAG CIBERSAM, Sant Boi de Llobregat, Spain
B. Gohier
Affiliation:
Department of Psychiatry, CHRU Angers, Angers, France
M. Tropeano
Affiliation:
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK
M.L. Phillips
Affiliation:
Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
S. Surguladze
Affiliation:
Cygnet Health Care, London, UK

Abstract

Introduction

Genetic polymorphisms of the catechol-O-methyltransferase gene (COMT Val158Met) and the serotonin transporter linked promoter region (5-HTTLPR) have been reported to influence the gray matter volumes of amygdala and hippocampus, but the studies have been inconsistent.

Aim

To elucidate the effects of COMT and 5-HTTLPR on regional gray matter volumes in the same sample of healthy individuals.

Methods

We conducted a diffeomorphic anatomic registration through exponentiated Lie algebra (DARTEL) voxel-based morphometry (VBM) study of the effects of COMT and 5-HTTLPR polymorphisms and their interaction on the gray matter volumes of 91 healthy controls.

Results

A small increase of gray matter volume in right angular gyrus was detected in carriers of the Met allele of COMT, and no main effects of 5-HTTLPR on gray matter volume were detected. The effects of the interaction between COMT and 5-HTTLPR on gray matter volume were large and mainly involved bilateral amygdala and hippocampus.

[COMT × 5-HTTLPR effects on gray matter volume].

Conclusions

The effects of the genetic interaction found in this study might explain the relative inconsistency in the results from previous studies, and suggest further research into genetic interactions.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1 - 2
Copyright
Copyright © European Psychiatric Association 2012
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