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P02-336 Longitudinal voxel - based morphometry to evaluate progressive gray mater changes in first - episode schizophrenia

Published online by Cambridge University Press:  16 April 2020

Y. Kawasaki
Affiliation:
Neuropsychiatry, Kanazawa Medical University, Uchinada, Japan Neuropsychiatry, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
M. Suzuki
Affiliation:
Neuropsychiatry, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
T. Takahashi
Affiliation:
Neuropsychiatry, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
K. Nakamura
Affiliation:
Neuropsychiatry, University of Toyama, Toyama, Japan

Abstract

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Background

Although longitudinal magnetic resonance imaging (MRI) studies have shown that various brain regions undergo progressive tissue loss during the early phases of schizophrenia, regional pattern of these changes remain unclear.

Methods

Longitudinal MRI data were obtained from 18 (12 males and 6 females) patients with first-episode schizophrenia and 20 (11 males and 9 females) healthy controls and at baseline and follow-up with mean scan interval of 2.7 years. To compare gray matter changes over time between patients and controls were evaluated with voxel-based morphometry (VBM) using SPM8 following the longitudinal DARTEL protocol.

Results

In both groups of patient and control longitudinal gray mater reduction was observed in various brain regions including lateral and medial frontal regions and superior temporal region. Excessive decrease in gray matter was found in patients as compared to healthy controls in the left superior temporal region and right inferior frontal region.

Discussion

Our findings suggest that there are differing longitudinal gray matter changes in patients with schizophrenia during the early phases of the illness as compared to healthy individuals.

Type
Research Article
Copyright
Copyright © European Psychiatric Association 2011
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