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P01-256 - Long-term influence of rats with newborn fluoxetine exposure at different period

Published online by Cambridge University Press:  17 April 2020

J. Tang
Affiliation:
Guangdong Armed Police Forces Hospital, Guangzhou Wuhan University, Wuhan, China
G. Wang
Affiliation:
Wuhan University, Wuhan, China
Z. Liu
Affiliation:
Wuhan University, Wuhan, China
C. Shu
Affiliation:
Wuhan University, Wuhan, China

Abstract

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Objective

To evaluate newborn fluoxetine exposure at different period on development and behavior of adult rats.

Methods

Male rat pups were randomized to be treated once daily with fluoxetine(s.c.) or saline(s.c.) during postnatal day 1∼7 and postnatal day 8∼21. Recorded the body weight. Starting at 90 days of age, all rats were tested with several experimental facilities, including open field test, elevated-plus maze, novelty- suppressed feeding test and forced swim test.

Results

:

  1. 1 Weight gain of rats with fluoxetine exposure during postnatal day 1∼7 were lower than controls (P<0.05).

  2. 2 Exploratory behavior decreased and depression anxiety behavior increased in adult rats with neonatal fluoxetine exposure (P<0.05), and more severe with postnatal day 1∼7 exposure (P<0.05).

Conclusions

Newborn fluoxetine exposure may result badness weight gain and depression anxiety behavior in adult rats, and the earlier exposure may accompany the larger risk.

Type
Child and adolescent psychiatry
Copyright
Copyright © European Psychiatric Association 2010
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