Substance dependence (SD) is one of the commonest comorbidities among patients with Anxiety Disorders (AD). Treating patients' co-occurring Anxiety disorders may reduce their substance craving and taking and enhance their over all outcomes. A methodical, staged screening and assessment can ease the diagnostic challenge of distinguishing the symptoms of anxiety disorders from manifestations of substance intoxication and withdrawal. This study was carried out on total of 561 substance dependence patients who were screened for Anxiety disorders by DSM IV based MINI Plus interview. The statistical analysis of the data was done by using Chi-square test χ2 test. The study revealed that 62.56% (n=351) had psychiatric comorbidity, with Anxiety disorders comorbid in 27.35% (n=96) dually diagnosed patients. Out of these 96 patients with comorbid anxiety disorders, 44.79% (n=43) had PTSD (Post Traumatic Stress disorder), 30.20% (n=29) had GAD (Generalized Anxiety Disorder), 13.54% (n=13) had OCD (0bsessive Compulsive disorder) and 11.45% (n=11) had panic disorder as comorbid diagnosis. Most of these patients with dual diagnosis of Anxiety Disorders and substance dependence 69.79% (n=67) belonged to < 35 year age group. Majority were males and unmarried. Illiterate patients out numbered educated. Most of the patients in this study were unemployed. Most common substances used by these dually diagnosed patients were cannabis followed by combination of opioids & benzodiazepines.