Hostname: page-component-848d4c4894-m9kch Total loading time: 0 Render date: 2024-05-15T07:17:29.259Z Has data issue: false hasContentIssue false
  • English
  • Français

Metabotropic Glutamate Receptor-mediated LTD Involves two Interacting Ca2+ Sensors, NCS-1 and PICK1

Published online by Cambridge University Press:  16 April 2020

J. Jo ,
S. Heon ,
M.J. Kim ,
G.H. Son ,
Y. Park ,
J.M. Henley ,
J.L. Weiss ,
M. Sheng ,
G.L. Collingridge  and
K. Cho
J. Jo
Affiliation:
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine & Dentistry, University of Bristol, Bristol, UK
S. Heon
Affiliation:
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine & Dentistry, University of Bristol, Bristol, UK
M.J. Kim
Affiliation:
The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
G.H. Son
Affiliation:
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine & Dentistry, University of Bristol, Bristol, UK
Y. Park
Affiliation:
Biomedical Science, University of Sheffield, Sheffield, UK
J.M. Henley
Affiliation:
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of BristolBristol, Bristol, UK
J.L. Weiss
Affiliation:
Biomedical Science, University of Sheffield, Sheffield, UK
M. Sheng
Affiliation:
The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
G.L. Collingridge
Affiliation:
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of BristolBristol, Bristol, UK
K. Cho
Affiliation:
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine & Dentistry, University of Bristol, Bristol, UK MRC Centre for Synaptic Plasticity, Department of Anatomy, University of BristolBristol, Bristol, UK

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

There are two major forms of long-term depression (LTD) of synaptic transmission in the central nervous system, which require activation of either N-methyl-D-aspartate receptors (NMDARs) or metabotropic glutamate receptors (mGluRs). In synapses in the perirhinal cortex we have directly compared the Ca2+ signalling mechanisms involved in NMDAR-LTD and mGluR-LTD. Whilst both forms of LTD involve Ca2+ release from intracellular stores the Ca2+ sensors involved are different; NMDAR-LTD involves calmodulin, whilst mGluR-LTD involves the neuronal Ca2+ sensor (NCS) protein NCS-1. In addition, there is a specific requirement for IP3 and PKC as well as protein interacting with C-kinase (PICK-1) in mGluR-LTD. NCS-1 binds directly to PICK1, via its BAR domain, in a Ca2+-dependent manner. Furthermore, the NCS-1-PICK1 association is stimulated by activation of mGluRs, but not NMDARs, and introduction of a PICK1 BAR domain fusion protein specifically blocks mGluR-LTD. Thus, NCS-1 is a component of a novel mechanism involved in mGluR-LTD.

Type
S17-01
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E84
Copyright
Copyright © European Psychiatric Association 2009
Submit a response

Comments

No Comments have been published for this article.