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Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder – a preliminary two-ligand SPECT study

Published online by Cambridge University Press:  15 April 2020

P.C. Hsieh ,
K.C. Chen ,
T.L. Yeh ,
I.H. Lee ,
P.S. Chen ,
W.J. Yao ,
N.-T. Chiu ,
C.-C. Chen ,
M.-H. Liao  and
Y.K. Yang
P.C. Hsieh
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan
K.C. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
T.L. Yeh
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
I.H. Lee
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
P.S. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
W.J. Yao
Affiliation:
Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
N.-T. Chiu
Affiliation:
Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
C.-C. Chen
Affiliation:
Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, Taoyuan, Taiwan
M.-H. Liao
Affiliation:
Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, Taoyuan, Taiwan
Y.K. Yang*
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
*
*Corresponding author. Tel.: +886 6 2353535×5213; fax: +886 6 2759259. E-mail address:ykyang@mail.ncku.edu.tw (Y.K. Yang).
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Abstract

Purpose

Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls. In addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. The aim of this study was to examine the availabilities of midbrain SERT and striatal DAT in healthy subjects with and without a first-degree family history of MDD.

Methods

Eight healthy subjects with first-degree relatives with MDD and 16 sex- and age-matched healthy controls were recruited. The availabilities of SERT and DAT were approximated using SPECT, employing [123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [99mTc] TRODAT-1 as the ligands, respectively. There are missing data for one participant with a first-degree family history of MDD from the ADAM study, due to a lack of the radio-ligand at the time of experiment.

Results

SERT availability in the midbrain was significantly lower in subjects with a first-degree family history of MDD than in healthy subjects. However, DAT availability was no different between two groups.

Conclusions

The results with regard to the midbrain SERT level suggest the heritability of MDD.

Keywords

Serotonin transporterDopamine transporterSPECTFamily history of major depressive disorder
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 7 , September 2014 , pp. 414 - 418
Copyright
Copyright © 2013 Elsevier Masson SAS

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