Hostname: page-component-77c89778f8-5wvtr Total loading time: 0 Render date: 2024-07-19T14:57:57.324Z Has data issue: false hasContentIssue false

Global arginine bioavailability ratio is decreased in patients with major depressive disorder

Published online by Cambridge University Press:  23 March 2020

T. Ali-Sisto
Affiliation:
University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland
T. Tolmunen
Affiliation:
University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland Kuopio University Hospital, Department of psychiatry, Kuopio, Finland
H. Viinamäki
Affiliation:
University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland Kuopio University Hospital, Department of psychiatry, Kuopio, Finland
P. Mäntyselkä
Affiliation:
University of Eastern Finland, Primary Health Care Unit, Kuopio, Finland Kuopio University Hospital, Primary Health Care Unit, Kuopio, Finland
V. Velagapudi
Affiliation:
Institute for Molecular Medicine Finland, Metabolomics unit, Helsinki, Finland
L. Soili
Affiliation:
University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland Kuopio University Hospital, Department of psychiatry, Kuopio, Finland

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

The global arginine bioavailability ratio (GABR) is used to estimate arginine supply. Arginine is precursor to nitric oxide (NO) that has been suggested to play a role in major depressive disorder (MDD). NO also participates in neuronal, inflammatory and cardioprotective functions.

Objectives

To compare GABR between:

– D patients and non-depressed controls;

– remitted and non-remitted MDD patients;

– baseline and follow-up within remitted and non-remitted MDD groups.

Aims

To investigate the role of NO production in MDD.

Methods

The sample comprised 99 MDD patients and 253 non-depressed controls (Beck Depression Inventory scores < 10) aged 20–71 years. Altogether, 78 patients returned for the follow-up; 33 were remitted and 45 non-remitted. GABR was calculated from serum levels of arginine, citrulline and ornithine, which were analysed using ultra-performance liquid chromatography. Differences between the study groups were examined using logistic regression adjusted for age, gender, smoking, alcohol use, physical exercise and glycated haemoglobin. The follow-up regression analyses were adjusted for age, gender and physical exercise.

Results

Lowered GABR was associated with belonging to the MDD group (OR 0.13, 95% CI 0.03–0.50). Exclusion of participants using anti-depressants that were associated with measured metabolites did not change the results. Over the follow-up period, the remitted and non-remitted groups both showed an increase in GABR (Z = –.53, P < 0.001 and Z = –3.00, P = 0.003, respectively).

Conclusions

Decreased GABR may characterise MDD. This could affect neuronal, immunological and cardioprotective functions of NO.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster viewing: Cultural psychiatry
Copyright
Copyright © European Psychiatric Association 2017
Submit a response

Comments

No Comments have been published for this article.