Skip to main content Accessibility help
×
Home
Hostname: page-component-747cfc64b6-dwt4q Total loading time: 0.25 Render date: 2021-06-16T20:28:15.086Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Article contents

GABRB2 in Schizophrenia and Bipolar Disorder: Disease Association, Gene Expression and Clinical Correlations

Published online by Cambridge University Press:  16 April 2020

J.-H. Chen
Affiliation:
Department of Biochemistry and Applied Genomics Center, Fok Ying Tung Graduate School, the Hong Kong University of Science and Technology, Hong Kong, China
S.-Y. Tsang
Affiliation:
Department of Biochemistry and Applied Genomics Center, Fok Ying Tung Graduate School, the Hong Kong University of Science and Technology, Hong Kong, China
C.-Y. Zhao
Affiliation:
Department of Biochemistry and Applied Genomics Center, Fok Ying Tung Graduate School, the Hong Kong University of Science and Technology, Hong Kong, China
F.W. Pun
Affiliation:
Department of Biochemistry and Applied Genomics Center, Fok Ying Tung Graduate School, the Hong Kong University of Science and Technology, Hong Kong, China
Z.-L. Yu
Affiliation:
Department of Biochemistry and Applied Genomics Center, Fok Ying Tung Graduate School, the Hong Kong University of Science and Technology, Hong Kong, China
L.-L. Mei
Affiliation:
Department of Biochemistry and Applied Genomics Center, Fok Ying Tung Graduate School, the Hong Kong University of Science and Technology, Hong Kong, China
W.-S. Lo
Affiliation:
Department of Biochemistry and Applied Genomics Center, Fok Ying Tung Graduate School, the Hong Kong University of Science and Technology, Hong Kong, China
S.-K. Ng
Affiliation:
Department of Biochemistry and Applied Genomics Center, Fok Ying Tung Graduate School, the Hong Kong University of Science and Technology, Hong Kong, China
H. Liu
Affiliation:
Ankang Hospital, Jining, China
G. Stöber
Affiliation:
Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
H. Xue
Affiliation:
Department of Biochemistry and Applied Genomics Center, Fok Ying Tung Graduate School, the Hong Kong University of Science and Technology, Hong Kong, China

Abstract

Aims:

Previously the GABA(A) receptor beta-2 subunit gene GABRB2 was found to be associated with schizophrenia (SCZ). for SNPs and haplotypes in GRBRB2, the associations with bipolar disorder (BPD), the functional consequences on GABRB2 expression and their relationship to demographic and clinical characteristics in BPD and SCZ remain to be elucidated.

Method:

Case-control analysis was performed for association study of GABRB2 with BPD, and its mRNA expression in postmortem BPD brains was examined using quantitative real-time PCR. Quantitative trait analysis was subsequently employed to assess the covariate effects of demographic and clinical characteristics on genotypic correlation of GABRB2 expression in SCZ and BPD.

Results:

Significant association of GABRB2 with BPD and reduction in GABRB2 mRNA expression in BPD brains were observed in the present study. Duration of illness (DOI) was found to be a significant covariate for the correlation of the disease-associated SNPs rs1816071, rs1816072 and rs187269 with GABRB2 expression in both SCZ and BPD. for individuals with homozygous major genotypes of these SNPs, while GABRB2 expression increased with age in the controls, it decreased with DOI and age in SCZ, and with DOI in BPD. with age of onset as covariate, these three SNPs were significantly correlated with antipsychotic dosage in SCZ.

Conclusion:

These results have thus revealed correlations of GABRB2 SNPs and expression not only with the occurrence of SCZ and BPD, but also with the clinical characteristics of patients, therefore providing support for a shared etiological role played by the gene in both diseases.

Type
P03-124
Copyright
Copyright © European Psychiatric Association 2009
Submit a response

Comments

No Comments have been published for this article.
You have Access

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

GABRB2 in Schizophrenia and Bipolar Disorder: Disease Association, Gene Expression and Clinical Correlations
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

GABRB2 in Schizophrenia and Bipolar Disorder: Disease Association, Gene Expression and Clinical Correlations
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

GABRB2 in Schizophrenia and Bipolar Disorder: Disease Association, Gene Expression and Clinical Correlations
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *