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Effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression

Published online by Cambridge University Press:  13 August 2021

A. Sikora ,
S. Fedorov ,
O. Pityk  and
M. Vynnyk
A. Sikora*
Affiliation:
Psychiatry, Narcology And Medical Psychology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
S. Fedorov
Affiliation:
Postgraduate Therapy, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
O. Pityk
Affiliation:
Psychiatry, Narcology And Medical Psychology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
M. Vynnyk
Affiliation:
Psychiatry, Narcology And Medical Psychology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
*
*Corresponding author.

Abstract

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Introduction

Several studies have shown impaired cytokine status in both patients with depression and chronic heart failure (HF).

Objectives

to study the effect of vortioxetine on the level of pro-inflammatory cytokines: interleukin -1β (IL-1β) and interleukin - 6 (IL-6).

Methods

there were examined 80 patients with HF with reduced ejection fraction (HFrEF) of ischemic genesis with functional class (FC) II-III (NYHA), 37 patients were without depression, 43 - with mild or moderate depressive disorders. Those with mild or moderate depressive disorders were divided into 2 subgroups: 21 patients received psychotherapy, 22 patients, in addition to psychotherapy, were prescribed vortioxetine at a dose of 10 mg / day in the morning after meals. The control group consisted of 20 healthy individuals. The level of cytokines in the blood was determined by ELISA method.

Results

Patients with CHF have an increase in levels of pro-inflammatory cytokines. Thus, the concentration in the serum of IL-1β was 2.3 times higher than the same indicator in the control group: (56.45 ± 4.17) pg / ml, against (24.71 ± 4.21) pg / ml p <0.001). Depression caused an additional increase in the levels of IL-1β by 13.5% (p <0.05) and IL-6 - by 17.3% (p <0.01). Additional administration of vortioxetine caused a more rapid decrease in blood levels of both IL-1β (HR 0.87 [95% CI 0.72-0.97; p = 0.034]) and IL-6 (HR 0.81 [95% CI 0.68-0.93; p = 0.029]).

Conclusions

Thus, vortioxetine causes a decrease in the concentration of pro-inflammatory cytokines IL-1β and IL-6 in patients with HF and comorbid depression.

Disclosure

No significant relationships.

Keywords

Depressioncomorbiditycytokinesheart failure
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S91
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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