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Does Vitamin D matter? The role of calcium homeostasis imbalance in clinical severity of psychiatric patients

Published online by Cambridge University Press:  01 September 2022

G. Altucci*
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
L. Giannelli
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
C. Palummo
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
A. Di Cerbo
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
S. Agnese
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
S. Cipolla
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
M. Fabrazzo
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
F. Perris
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
F. Catapano
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
M. Luciano
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
G. Sampogna
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
A. Fiorillo
Affiliation:
University of Campania “Luigi Vanvitelli”, Department Of Psychiatry, Naples, Italy
*
*Corresponding author.

Abstract

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Introduction

Vitamin D modulates the biosynthesis of neurotransmitters and neurotrophic factors and it is involved in the modulation of inflammatory responses, with a potential impact on clinical status of patients with severe mental disorders. Moreover, available evidences report that decreased blood levels of Vitamin D are associated to a worse course of psychotic and affective disorders.

Objectives

We assessed calcium homeostasis imbalance in a sample of inpatients and outpatients, referring to the Department of Psychiatry of University of Campania “Luigi Vanvitelli” in order to explore levels of Calcium, PTH and Vitamin D and their influence in clinical severity among this different subgroups.

Methods

All patients were administered The Brief Psychiatric Rating Scale (BPRS) to assess different domains of psychopathology. Vitamin D, Calcium and PTH levels were assessed in all patients. An-ad hoc schedule was administered for socio-demographic and clinical characteristics.

Results

The total sample consisted of 152 patients (75 males and 77 females with 47.3 ± 14.4 age at admission, 74 inpatients and 78 outpatients). Patients with lower level of Vitamin D are more likely to present higher number of relapses (p<0.05) and to be inpatients (<0.01). Finally, serum levels of Vitamin D were negatively correlated with all the BPRS subscales (p < 0.01).

Conclusions

Lower levels of Vitamin D correlate with a worse clinical outcome of patients with different psychiatric diagnosis. Our results highlight the importance to routinely assess PTH, Vit D and calcium levels, especially in inpatients. Moreover, Vitamin D may represent a valid add-on treatment for these patients.

Disclosure

No significant relationships.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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