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The course of depressive symptoms and prescribing patterns of antidepressants in schizophrenia in a one-year follow-up study

Published online by Cambridge University Press:  15 April 2020

I.M. Lako ,
K. Taxis ,
R. Bruggeman ,
H. Knegtering ,
H. Burger ,
D. Wiersma  and
C.J. Slooff
I.M. Lako
Affiliation:
Rob Giel Research Center (RGOc), Department of Psychiatry (UCP), University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands Division of Pharmacotherapy and Pharmaceutical Care, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands
K. Taxis*
Affiliation:
Division of Pharmacotherapy and Pharmaceutical Care, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands
R. Bruggeman
Affiliation:
Rob Giel Research Center (RGOc), Department of Psychiatry (UCP), University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands Division of Pharmacotherapy and Pharmaceutical Care, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands
H. Knegtering
Affiliation:
Rob Giel Research Center (RGOc), Department of Psychiatry (UCP), University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands Lentis Center for Mental Health Care and UMCG Neuroimaging Center, University of Groningen, Hereweg 80, 9725 AG, Groningen, The Netherlands
H. Burger
Affiliation:
Rob Giel Research Center (RGOc), Department of Psychiatry (UCP), University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands Department of Epidemiology, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
D. Wiersma
Affiliation:
Rob Giel Research Center (RGOc), Department of Psychiatry (UCP), University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
C.J. Slooff
Affiliation:
Rob Giel Research Center (RGOc), Department of Psychiatry (UCP), University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands Department of Psychotic Disorders, Mental Health Centre Assen (GGZ Drenthe), Dennenweg 9, 9404 LA, Assen, The Netherlands
*
*Corresponding author. Tel.: +31 50 3638205; fax: +31 50 3632772. E-mail address: k.taxis@rug.nl (K. Taxis).
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Abstract

Background

Antidepressants are frequently prescribed in patients with psychotic disorders, but little is known about their effects in routine clinical practice. The objective was to investigate the prescribing patterns of antidepressants in relation to the course of depressive symptoms in patients with psychotic disorders.

Methods

A cohort of 214 Dutch patients with psychotic disorders received two assessments of somatic and psychiatric health, including a clinician-rated screening for depressive symptoms, as part of annual routine outcome monitoring.

Results

Depressive symptoms were prevalent among 43% (93) of the patients. Antidepressants were prescribed for 40% (86) of the patients and the majority 83% (71) continued this therapy after one year. Multivariable analysis showed that patients with more severe psychopathology had a higher risk to develop depressive symptoms the following year (OR [95% CI]=0.953 [0.912–0.995]). For patients with depressive symptoms at baseline, polypharmacy was a potential risk factor to keep having depressive symptoms (OR [95% CI]=1.593 [1.123–2.261]). Antidepressant use was not an independent predictor in both analyses.

Conclusions

Routine outcome monitoring in patients with psychotic disorders revealed a high prevalence of depressive symptoms. Antidepressants were frequently prescribed and continued in routine clinical practice.

Keywords

SchizophreniaPsychosisPsychopharmacologyAntidepressantPrescribing patternsClinical practice
Type
Original article
Information
European Psychiatry , Volume 27 , Issue 4 , May 2012 , pp. 240 - 244
Copyright
Copyright © Elsevier Masson SAS 2012

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