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The correlation of the endophenotypes to the at-risk haplotypes

Published online by Cambridge University Press:  16 April 2020

W. Maier ,
M. Wagner ,
O. Gruber ,
P. Falkai  and
S.G. Schwab
W. Maier
Affiliation:
Department of Psychiatry, University of Bonn, Bonn, Germany
M. Wagner
Affiliation:
Department of Psychiatry, University of Bonn, Bonn, Germany
O. Gruber
Affiliation:
Department of Psychiatry, Saarland University, Bad Homburg, Germany
P. Falkai
Affiliation:
Department of Psychiatry, University of Goettingen, Goettingen, Germany
S.G. Schwab
Affiliation:
Western Australian Institute of Medical Research, University of Western Australia, Perth, Australia

Abstract

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Although a series of DNA-sequence variants in proposed disposition genes for schizophrenia have been identified, the mechanisms to translate the genetic vulnerability for schizophrenia to the manifestation of the disease remain obscure. The analysis of the relationship of disease-associated alleles and combinations of alleles (haplotypes) to the clinical features and associated neurobiological correlates offer a tool to increase our understanding of the aetiology of schizophrenia.

We will explore this relationship in a series of case-control samples by (1) extracting schizophrenia-associated alleles and haplotypes of postulated susceptibility and modifying genes, (2) testing these identified genetic markers for association with neuropsychological and neuroimaging features of schizophrenia.

Type
S05. Symposium: The Clinical Significance of At-Risk Haplotypes in Schizophrenia
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S7
Copyright
Copyright © European Psychiatric Association 2007
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